Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/113268
DC Field | Value | Language |
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dc.contributor.author | Laranjeira, Paula | - |
dc.contributor.author | Dos Santos, Francisco | - |
dc.contributor.author | Salvador, Maria João | - |
dc.contributor.author | Simões, Irina N. | - |
dc.contributor.author | Cardoso, Carla M. P. | - |
dc.contributor.author | Silva, Bárbara M. | - |
dc.contributor.author | Henriques-Antunes, Helena | - |
dc.contributor.author | Corte-Real, Luísa | - |
dc.contributor.author | Couceiro, Sofia | - |
dc.contributor.author | Monteiro, Filipa | - |
dc.contributor.author | Santos, Carolina | - |
dc.contributor.author | Santiago, Tânia | - |
dc.contributor.author | Silva, José A. P. da | - |
dc.contributor.author | Paiva, Artur | - |
dc.date.accessioned | 2024-02-12T09:55:20Z | - |
dc.date.available | 2024-02-12T09:55:20Z | - |
dc.date.issued | 2023-04-30 | - |
dc.identifier.issn | 2227-9059 | - |
dc.identifier.uri | https://hdl.handle.net/10316/113268 | - |
dc.description.abstract | Systemic sclerosis (SSc) is an immune-mediated disease wherein T cells are particularly implicated, presenting a poor prognosis and limited therapeutic options. Thus, mesenchymal-stem/stromal-cell (MSC)-based therapies can be of great benefit to SSc patients given their immunomodulatory, anti-fibrotic, and pro-angiogenic potential, which is associated with low toxicity. In this study, peripheral blood mononuclear cells from healthy individuals (HC, n = 6) and SSc patients (n = 9) were co-cultured with MSCs in order to assess how MSCs affected the activation and polarization of 58 different T cell subsets, including Th1, Th17, and Treg. It was found that MSCs downregulated the activation of 26 out of the 41 T cell subsets identified within CD4+, CD8+, CD4+CD8+, CD4-CD8-, and γδ T cells in SSc patients (HC: 29/42) and affected the polarization of 13 out of 58 T cell subsets in SSc patients (HC: 22/64). Interestingly, SSc patients displayed some T cell subsets with an increased activation status and MSCs were able to downregulate all of them. This study provides a wide-ranging perspective of how MSCs affect T cells, including minor subsets. The ability to inhibit the activation and modulate the polarization of several T cell subsets, including those implicated in SSc's pathogenesis, further supports the potential of MSC-based therapies to regulate T cells in a disease whose onset/development may be due to immune system's malfunction. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | This research was funded by the MSCellProduction project (POCI-01-0247-FEDER-038313) for Portugal 2020, under the Programa Operacional Competitividade e Internacionalização, grating the amount of EUR 547,571.40, of which EUR 327,435.43 came from the European Regional Development Fund. Funding was also provided by the CellTherapy4COVID19 project (POCI-01-02B7-FEDER- 048816) of Portugal 2020 under the Programa Operacional Competitividade e Internacionalização, grating the amount of EUR 430.523,50, of which EUR 344.418,80 came from the European Regional Development Fund | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | mesenchymal stromal cells (MSCs) | pt |
dc.subject | mesenchymal stemcells | pt |
dc.subject | immunomodulatory potential | pt |
dc.subject | systemic sclerosis | pt |
dc.subject | T cells | pt |
dc.subject | T cell polarization | pt |
dc.subject | T cell activation | pt |
dc.subject | Treg; Th17 | pt |
dc.subject | cellular therapy | pt |
dc.title | Umbilical-Cord-Derived Mesenchymal Stromal Cells Modulate 26 Out of 41 T Cell Subsets from Systemic Sclerosis Patients | pt |
dc.type | article | pt |
degois.publication.firstPage | 1329 | pt |
degois.publication.issue | 5 | pt |
degois.publication.title | Biomedicines | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/biomedicines11051329 | - |
degois.publication.volume | 11 | pt |
dc.date.embargo | 2023-04-30 | * |
dc.identifier.pmid | 37239000 | - |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.orcid | 0000-0002-1136-6118 | - |
crisitem.author.orcid | 0000-0002-2782-6780 | - |
crisitem.author.orcid | 0000-0002-6562-5859 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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UmbilicalCordDerived-Mesenchymal-Stromal-Cells-Modulate-26-Out-of-41-T-Cell-Subsets-from-Systemic-Sclerosis-PatientsBiomedicines.pdf | 13.46 MB | Adobe PDF | View/Open |
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