Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/112648
Title: | The NDR/LATS protein kinases in neurobiology: Key regulators of cell proliferation, differentiation and migration in the ocular and central nervous system | Authors: | Santos, Paulo F. Fazendeiro, Beatriz Luca, Francis C. Ambrósio, A. Francisco Léger, Hélène |
Keywords: | Nuclear Dbf2-related (NDR) kinase; Large tumour suppressor (LATS) kinase; Hippo Pathway; Retina Central Nervous System (CNS) | Issue Date: | Jun-2023 | Publisher: | Elsevier | Project: | 2022.06170.PTDC NIH, USA (grant RO1-GMO97327) grant from the University of Pennsylvania School of Veterinary Medicine Research Foundation, USA |
Serial title, monograph or event: | European Journal of Cell Biology | Volume: | 102 | Issue: | 2 | Abstract: | Nuclear Dbf2-related (NDR) kinases are a subgroup of evolutionarily conserved AGC protein kinases that regulate various aspects of cell growth and morphogenesis. There are 4 NDR protein kinases in mammals, LATS1, LATS2 and STTK8/NDR1, STK38L/NDR2 protein kinases. LATS1 and 2 are core components of the well-studied Hippo pathway, which play a critical role in the regulation of cell proliferation, differentiation, and cell migration via YAP/TAZ transcription factor. The Hippo pathways play an important role in nervous tissue development and homeostasis, especially with regard to the central nervous system (CNS) and the ocular system. The ocular system is a very complex system generated by the interaction in a very tightly coordinated manner of numerous and diverse developing tissues, such as, but not limited to choroidal and retinal blood vessels, the retinal pigmented epithelium and the retina, a highly polarized neuronal tissue. The retina development and maintenance require precise and coordinated regulation of cell proliferation, cell death, migration, morphogenesis, synaptic connectivity, and balanced homeostasis. This review highlights the emerging roles of NDR1 and NDR2 kinases in the regulation of retinal/neuronal function and homeostasis via a noncanonical branch of the Hippo pathway. We highlight a potential role of NDR1 and NDR2 kinases in regulating neuronal inflammation and as potential therapeutic targets for the treatment of neuronal diseases. | URI: | https://hdl.handle.net/10316/112648 | ISSN: | 01719335 | DOI: | 10.1016/j.ejcb.2023.151333 | Rights: | openAccess |
Appears in Collections: | I&D ICBR - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais FCTUC Ciências da Vida - Artigos em Revistas Internacionais I&D IBILI - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
The NDR LATS protein kinases in neurobiology.pdf | 2.39 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
3
checked on Oct 7, 2024
WEB OF SCIENCETM
Citations
3
checked on Oct 2, 2024
Page view(s)
84
checked on Oct 16, 2024
Download(s)
42
checked on Oct 16, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License