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https://hdl.handle.net/10316/112187
Title: | Significance of Furin Expression in Thyroid Neoplastic Transformation | Authors: | Azevedo, Maria Teresa Macedo, Sofia Canberk, Sule Cardoso, Luís Gaspar, Tiago Bordeira Pestana, Ana Batista, Rui Sobrinho-Simões, Manuel Soares, Paula |
Keywords: | ACE2; TMPRSS2; Furin; thyroid; thyroid neoplasms | Issue Date: | 1-Aug-2023 | Publisher: | MDPI | Project: | This work was supported by Portuguese funds through FCT in the framework of a Ph.D. grant to SM (SFRH/BD/137802/2018). The project was funded by FCT through RESEARCH4COVID- 19 Special Programme, Project nº625. This research was partly supported by the project “Cancer Research on Therapy Resistance: From Basic Mechanisms to Novel Targets”—NORTE-01-0145- FEDER-000051-Consórcio POR-TO.CCC—Porto Comprehensive Cancer Center Raquel Seruca, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) (NORTE- 01-0145-FEDER-072678). | Serial title, monograph or event: | Cancers | Volume: | 15 | Issue: | 15 | Abstract: | Angiotensin-Converting Enzyme 2 (ACE2), Transmembrane Serine Protease 2 (TMPRSS2), and Furin were known to be key players in the SARS-CoV-2 infection, and the thyroid gland was revealed to be one of the relevant targets of the virus. Regardless of the viral infection, the expression of these molecules in the thyroid gland and their putative role in the neoplastic transformation of the thyrocytes has not been thoroughly explored. In this work, we aimed to characterize the mRNA and protein expression pattern of ACE2, TMPRSS2, and Furin in a series of patients with thyroid lesions. Our main results revealed a significantly decreased expression of ACE2 mRNA in the thyroid neoplasms in comparison to normal adjacent tissue. Furin mRNA was significantly increased in thyroid neoplasms when compared to normal adjacent tissue. In addition, a higher Furin mRNA level in thyroid carcinomas was associated with the presence of lymph node metastasis. Furin mRNA expression revealed a high discriminatory power between adjacent tissue and neoplasms. Protein expression of these molecules did not correlate with mRNA expression. Our study shows the mRNA downregulation of ACE2 and overexpression of Furin in thyroid neoplasms. Further studies are required to clarify if Furin expression can be a potential diagnostic indicator in thyroid neoplasia. | URI: | https://hdl.handle.net/10316/112187 | ISSN: | 2072-6694 | DOI: | 10.3390/cancers15153909 | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
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Significance-of-Furin-Expression-in-Thyroid-Neoplastic-TransformationCancers.pdf | 5.96 MB | Adobe PDF | View/Open |
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