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Title: A mathematical model for a comprehensive approach to the dynamics of human colonic aberrant crypt foci
Authors: Figueiredo, Isabel N. 
Figueiredo, Pedro N. 
Leal, Carlos 
Urbano, José Miguel 
Keywords: Aberrant crypt foci; Logistic differential equation; Apoptosis index; Proliferation index; Colorectal cancer
Issue Date: 2008
Publisher: Centro de Matemática da Universidade de Coimbra
Citation: Pré-Publicações DMUC. 08-01 (2008)
Abstract: In this paper, we propose mathematical models for the growth dynamics of aberrant crypt foci in the human colon, as well as for some of their characteristics, namely the apoptosis and proliferation indices. The models rely on logistic type differential equations and clinical observations at different times, and can arguably be used as an auxiliary screening tool for colon cancer. We report several results using available medical data.
Rights: openAccess
Appears in Collections:FMUC Medicina - Vários
FCTUC Matemática - Vários

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