Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/109971
Title: | Thymoquinoneβ-Cyclodextrin Nanoparticles System: A Preliminary Study | Authors: | Cardoso, T. Galhano, C. I. C. Marques, M. F. Silva, A. Moreira da |
Keywords: | β-cyclodextrin; DSC; FTIR; inclusion compounds; PALS,; thymoquinone | Issue Date: | 2012 | Publisher: | Hindawi | Serial title, monograph or event: | Spectroscopy (New York) | Volume: | 27 | Abstract: | Thymoquinone is a natural product, the main constituent of Nigella sativa seeds, which exhibits anti-inflammatory and anticancer activities. Among several existing molecules capable of forming an inclusion compound structure, cyclodextrins are applied in the pharmaceutical industry either to increase solubility of hydrophobic molecules or to protect molecules from inactivation or degradation. β-Cyclodextrin is currently the most common cyclodextrin in pharmaceutical formulations and probably the best studied in humans. In order to study the properties of inclusion compounds based on cyclodextrins and thymoquinone Fourier Transform Infrared (FTIR), Ultraviolet-Visible, Positron Annihilation Lifetime (PAL) Spectroscopies and calorimetric studies by Differential Scanning Calorimetry (DSC) were used. The obtained results indicate the formation of a 1 : 1 inclusion compound between cyclodextrin and thymoquinone. PALS and DSC measurements also provided evidence of the inclusion compound’s activity. | URI: | http://hdl.handle.net/10316/109971 | ISSN: | 0712-4813 1875-922X |
DOI: | 10.1155/2012/902486 | Rights: | openAccess |
Appears in Collections: | I&D QFM-UC - Artigos em Revistas Internacionais FCTUC Física - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Thymoquinone-cyclodextrin-nanoparticles-system-A-preliminary-studySpectroscopy-New-York.pdf | 2.08 MB | Adobe PDF | View/Open |
Page view(s)
63
checked on Oct 9, 2024
Download(s)
21
checked on Oct 9, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License