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https://hdl.handle.net/10316/109841
Title: | Efeitos da semicarbazida no esqueleto de ratos Wistar em crescimento | Other Titles: | Effects of semicarbazide on skeleton of growing Wistar rats | Authors: | Ramos, A. Pereira, A. Cabrita, A. Silvério Capela e Silva, F. |
Keywords: | rat; Wistar; semicarbazide; osteolathyrism | Issue Date: | 2012 | Volume: | 64 | Issue: | 2 | Abstract: | The effects of semicarbazide hydrochloride on skeletal tissues were evaluated using Wistar rats. In the animals submitted to the administration of semicarbazide, radiological examination showed bone and articular alterations with growth plates enlargement. Histological exams showed irregular patterns and proliferation of chondrocytes and excessive accumulation of extracellular matrix. Immunohistochemical exams showed PCNA positive reaction in pre- and hypertrofic chondrocytes. These results confirm that semicarbazide induces important changes in skeletal tissues and that has potential utility in experimental osteolathryrism. | URI: | https://hdl.handle.net/10316/109841 | ISSN: | 0102-0935 | DOI: | 10.1590/S0102-09352012000200035 | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
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