Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/109841
DC FieldValueLanguage
dc.contributor.authorRamos, A.-
dc.contributor.authorPereira, A.-
dc.contributor.authorCabrita, A. Silvério-
dc.contributor.authorCapela e Silva, F.-
dc.date.accessioned2023-10-31T10:10:08Z-
dc.date.available2023-10-31T10:10:08Z-
dc.date.issued2012-
dc.identifier.issn0102-0935pt
dc.identifier.urihttps://hdl.handle.net/10316/109841-
dc.description.abstractThe effects of semicarbazide hydrochloride on skeletal tissues were evaluated using Wistar rats. In the animals submitted to the administration of semicarbazide, radiological examination showed bone and articular alterations with growth plates enlargement. Histological exams showed irregular patterns and proliferation of chondrocytes and excessive accumulation of extracellular matrix. Immunohistochemical exams showed PCNA positive reaction in pre- and hypertrofic chondrocytes. These results confirm that semicarbazide induces important changes in skeletal tissues and that has potential utility in experimental osteolathryrism.pt
dc.language.isoporpt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt
dc.subjectratpt
dc.subjectWistarpt
dc.subjectsemicarbazidept
dc.subjectosteolathyrismpt
dc.titleEfeitos da semicarbazida no esqueleto de ratos Wistar em crescimentopt
dc.title.alternativeEffects of semicarbazide on skeleton of growing Wistar ratspt
dc.typearticle-
degois.publication.firstPage499pt
degois.publication.lastPage504pt
degois.publication.issue2pt
dc.peerreviewedyespt
dc.identifier.doi10.1590/S0102-09352012000200035pt
degois.publication.volume64pt
dc.date.embargo2012-01-01*
uc.date.periodoEmbargo0pt
item.grantfulltextopen-
item.cerifentitytypePublications-
item.languageiso639-1pt-
item.openairetypearticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextCom Texto completo-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0001-5165-5849-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
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