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Title: Bisphosphonate-related osteonecrosis of the jaw: specificities
Authors: Paulo, Siri 
Abrantes, Ana M. 
Laranjo, Mafalda 
Carvalho, Lina 
Serra, Arménio 
Botelho, Maria Filomena 
Ferreira, Manuel Marques 
Keywords: bone; bisphosphonate; osteonecrosi; jaw; soft tissues
Issue Date: 23-Sep-2014
Publisher: PagePress
Serial title, monograph or event: Oncology Reviews
Volume: 8
Issue: 2
Abstract: Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a severe complication that has recently emerged in patients treated with intravenous bisphosphonates for malignant diseases. This complication usually presents after a minor local trauma during a dental treatment. Several etiopathogenic mechanisms of this pathological condition have been proposed, but no model can explain all morphological changes observed at the macroscopic and microscopic level. BRONJ is likely to be related to direct toxicity in the bone and soft tissue cells, due to nitrogen-containing bisphosphonates. This review elucidates the clinical indications and mechanism of action of bisphosphonates, reports some clinical diagnostic criteria for BRONJ, describe the histopathological criteria for BRONJ diagnosis, the potential triggering pathways and the available treatment strategies.
ISSN: 1970-5565
DOI: 10.4081/oncol.2014.254
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

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