Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/109517
DC FieldValueLanguage
dc.contributor.authorPaulo, Siri-
dc.contributor.authorAbrantes, Ana M.-
dc.contributor.authorLaranjo, Mafalda-
dc.contributor.authorCarvalho, Lina-
dc.contributor.authorSerra, Arménio-
dc.contributor.authorBotelho, Maria Filomena-
dc.contributor.authorFerreira, Manuel Marques-
dc.date.accessioned2023-10-18T11:09:45Z-
dc.date.available2023-10-18T11:09:45Z-
dc.date.issued2014-09-23-
dc.identifier.issn1970-5565pt
dc.identifier.urihttps://hdl.handle.net/10316/109517-
dc.description.abstractBisphosphonate-related osteonecrosis of the jaws (BRONJ) is a severe complication that has recently emerged in patients treated with intravenous bisphosphonates for malignant diseases. This complication usually presents after a minor local trauma during a dental treatment. Several etiopathogenic mechanisms of this pathological condition have been proposed, but no model can explain all morphological changes observed at the macroscopic and microscopic level. BRONJ is likely to be related to direct toxicity in the bone and soft tissue cells, due to nitrogen-containing bisphosphonates. This review elucidates the clinical indications and mechanism of action of bisphosphonates, reports some clinical diagnostic criteria for BRONJ, describe the histopathological criteria for BRONJ diagnosis, the potential triggering pathways and the available treatment strategies.pt
dc.language.isoengpt
dc.publisherPagePresspt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt
dc.subjectbonept
dc.subjectbisphosphonatept
dc.subjectosteonecrosipt
dc.subjectjawpt
dc.subjectsoft tissuespt
dc.titleBisphosphonate-related osteonecrosis of the jaw: specificitiespt
dc.typearticle-
degois.publication.firstPage254pt
degois.publication.issue2pt
degois.publication.titleOncology Reviewspt
dc.peerreviewedyespt
dc.identifier.doi10.4081/oncol.2014.254pt
degois.publication.volume8pt
dc.date.embargo2014-09-23*
uc.date.periodoEmbargo0pt
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypearticle-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextCom Texto completo-
item.languageiso639-1en-
crisitem.author.researchunitiNOVA4Health - Programme in Translational Medicine (iBET, CEDOC/FCM, IPOLFG and ITQB)-
crisitem.author.researchunitCEMMPRE - Centre for Mechanical Engineering, Materials and Processes-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0003-4185-7871-
crisitem.author.orcid0000-0003-0689-6007-
crisitem.author.orcid0000-0001-8349-4488-
crisitem.author.orcid0000-0001-8664-2757-
crisitem.author.orcid0000-0001-7202-1650-
crisitem.author.orcid0000-0002-5968-6161-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
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This item is licensed under a Creative Commons License Creative Commons