Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/109384
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Louros, Susana R. | - |
dc.contributor.author | Hooks, Bryan M | - |
dc.contributor.author | Litvina, Liza | - |
dc.contributor.author | Carvalho, Ana Luísa | - |
dc.contributor.author | Chen, Chinfei | - |
dc.date.accessioned | 2023-10-12T08:28:44Z | - |
dc.date.available | 2023-10-12T08:28:44Z | - |
dc.date.issued | 2014-06-12 | - |
dc.identifier.issn | 22111247 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/109384 | - |
dc.description.abstract | During development, neurons are constantly refining their connections in response to changes in activity. Experience-dependent plasticity is a key form of synaptic plasticity, involving changes in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) accumulation at synapses. Here, we report a critical role for the AMPAR auxiliary subunit stargazin in this plasticity. We show that stargazin is functional at the retinogeniculate synapse and that in the absence of stargazin, the refinement of the retinogeniculate synapse is specifically disrupted during the experience-dependent phase. Importantly, we found that stargazin expression and phosphorylation increased with visual deprivation and led to reduced AMPAR rectification at the retinogeniculate synapse. To test whether stargazin plays a role in homeostatic plasticity, we turned to cultured neurons and found that stargazin phosphorylation is essential for synaptic scaling. Overall, our data reveal an important role for stargazin in regulating AMPAR abundance and composition at glutamatergic synapses during homeostatic and experience-dependent plasticity. | pt |
dc.language.iso | eng | pt |
dc.relation | FCT and FEDER, Portugal (PEst-C/SAU/LA0001/2013-2014, PTDC/ SAU-NEU/099440/2008, and PTDC/NEU-NCM/0750/2012 to A.L.C.), | pt |
dc.relation | NIH (F31 NS048630 to B.M.H., and EY013613 and HD018655 to C.C.) | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt |
dc.subject.mesh | Animals | pt |
dc.subject.mesh | Calcium Channels | pt |
dc.subject.mesh | Cells, Cultured | pt |
dc.subject.mesh | Geniculate Bodies | pt |
dc.subject.mesh | Homeostasis | pt |
dc.subject.mesh | Mice | pt |
dc.subject.mesh | Neurons | pt |
dc.subject.mesh | Receptors, AMPA | pt |
dc.subject.mesh | Synapses | pt |
dc.subject.mesh | Long-Term Potentiation | pt |
dc.title | A role for stargazin in experience-dependent plasticity | pt |
dc.type | article | - |
degois.publication.firstPage | 1614 | pt |
degois.publication.lastPage | 1625 | pt |
degois.publication.issue | 5 | pt |
degois.publication.title | Cell Reports | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1016/j.celrep.2014.04.054 | pt |
degois.publication.volume | 7 | pt |
dc.date.embargo | 2014-06-12 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0001-8368-6666 | - |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
A role for stargazin in experience-dependent plasticity.pdf | 2.52 MB | Adobe PDF | View/Open |
Page view(s)
51
checked on May 8, 2024
Download(s)
23
checked on May 8, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License