Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/109363
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Abrantes, Ana M. | - |
dc.contributor.author | Tavares, Ludgero C. | - |
dc.contributor.author | Pires, Salomé | - |
dc.contributor.author | Casalta-Lopes, João | - |
dc.contributor.author | Mendes, Cândida | - |
dc.contributor.author | Simões, Marta | - |
dc.contributor.author | Grazina, Manuela M. | - |
dc.contributor.author | Carvalho, Rui A. | - |
dc.contributor.author | Botelho, Maria Filomena | - |
dc.date.accessioned | 2023-10-11T09:42:06Z | - |
dc.date.available | 2023-10-11T09:42:06Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 2314-6133 | pt |
dc.identifier.issn | 2314-6141 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/109363 | - |
dc.description.abstract | (13)C NMR isotopomer analysis was used to characterize intermediary metabolism in three colorectal cancer cell lines (WiDr, LS1034, and C2BBe1) and determine the "metabolic remodeling" that occurs under hypoxia. Under normoxia, the three colorectal cancer cell lines present high rates of lactate production and can be seen as "Warburg" like cancer cells independently of substrate availability, since such profile was dominant at both high and low glucose media contents. The LS1034 was the less glycolytic of the three cell lines and was the most affected by the event of hypoxia, raising abruptly glucose consumption and lactate production. The other two colorectal cell lines, WiDr and C2BBe1, adapted better to hypoxia and were able to maintain their oxidative fluxes even at the very low levels of oxygen. These differential metabolic behaviors of the three colorectal cell lines show how important an adequate knowledge of the "metabolic remodeling" that follows a given cancer treatment is towards the correct (re)design of therapeutic strategies against cancer. | pt |
dc.language.iso | eng | pt |
dc.publisher | Hindawi | pt |
dc.relation | PTDC/EBBEBI/ 115810/2009 | pt |
dc.relation | Centre of Investigation on Environment Genetics and Oncobiology (CIMAGO) | pt |
dc.relation | SFRH/BD/75300/2010 | pt |
dc.relation | SFRH/BD/66600/2009 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject.mesh | Carbon-13 Magnetic Resonance Spectroscopy | pt |
dc.subject.mesh | Cell Hypoxia | pt |
dc.subject.mesh | Cell Line, Tumor | pt |
dc.subject.mesh | Colorectal Neoplasms | pt |
dc.subject.mesh | Glucose | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Lactic Acid | pt |
dc.subject.mesh | Oxygen | pt |
dc.subject.mesh | Oxidation-Reduction | pt |
dc.title | Metabolic effects of hypoxia in colorectal cancer by 13C NMR isotopomer analysis | pt |
dc.type | article | - |
degois.publication.firstPage | 759791 | pt |
degois.publication.lastPage | 10 | pt |
degois.publication.title | BioMed Research International | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1155/2014/759791 | pt |
degois.publication.volume | 2014 | pt |
dc.date.embargo | 2014-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | Group for Monetary and Financial Studies | - |
crisitem.author.researchunit | CeBER – Centre for Business and Economics Research | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0003-4185-7871 | - |
crisitem.author.orcid | 0000-0002-2324-1259 | - |
crisitem.author.orcid | 0000-0001-7994-4650 | - |
crisitem.author.orcid | 0000-0003-1046-2551 | - |
crisitem.author.orcid | 0000-0002-1173-6481 | - |
crisitem.author.orcid | 0000-0003-1820-0353 | - |
crisitem.author.orcid | 0000-0001-7202-1650 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais FCTUC Ciências da Vida - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Metabolic-effects-of-hypoxia-in-colorectal-cancer-by-sup13supC-NMR-isotopomer-analysisBioMed-Research-International.pdf | 2.17 MB | Adobe PDF | View/Open |
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This item is licensed under a Creative Commons License