Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/109228
Título: | Isochromosome 17q in Chronic Lymphocytic Leukemia | Autor: | Alhourani, Eyad Rincic, Martina Melo, Joana B. Carreira, Isabel M. Glaser, Anita Pohle, Beate Schlie, Cordula Liehr, Thomas |
Data: | 2015 | Editora: | Hindawi | Projeto: | This paperwas supported in part by the KAAD | Título da revista, periódico, livro ou evento: | Leukemia Research and Treatment | Volume: | 2015 | Resumo: | In chronic lymphocytic leukemia (CLL), presence of acquired cytogenetic abnormalities may help to estimate prognosis. However, deletion of TP53 gene, which is associated with an aggressive course of the disease and poor prognosis along with a lack of response to treatment, is one of the alterations which may escape cytogenetic diagnoses in CLL. Thus, other techniques have emerged such as interphase fluorescence in situ hybridization (iFISH). Deletion of TP53 may but must not go together with the formation of an isochromosome i(17q); surprisingly this subgroup of patients was not in the focus of CLL studies yet. This study was about if presence of i(17q) could be indicative for a new subgroup in CLL with more adverse prognosis. As a result, TP53 deletion was detected in 18 out of 150 (12%) here studied CLL cases. Six of those cases (~33%) had the TP53 deletion accompanied by an i(17q). Interestingly, the cases with i(17q) showed a tendency towards more associated chromosomal aberrations. These findings may be the bases for follow-up studies in CLL patients with TP53 deletion with and without i(17q); it may be suggested that the i(17q) presents an even more adverse prognostic marker than TP53 deletion alone. | URI: | https://hdl.handle.net/10316/109228 | ISSN: | 2090-3219 | DOI: | 10.1155/2015/489592 | Direitos: | openAccess |
Aparece nas coleções: | FMUC Medicina - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Isochromosome-17q-in-Chronic-Lymphocytic-LeukemiaLeukemia-Research-and-Treatment.pdf | 1.53 MB | Adobe PDF | Ver/Abrir |
Visualizações de página
46
Visto em 8/mai/2024
Downloads
5
Visto em 8/mai/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Este registo está protegido por Licença Creative Commons