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Title: | Renoprotective Effects of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin: A Review in Type 2 Diabetes | Authors: | Mega, Cristina Teixeira-de-Lemos, Edite Fernandes, Rosa Reis, Flávio |
Issue Date: | 2017 | Publisher: | Hindawi | Project: | PEst-C/SAU/UI3282/2013 FCOMP-01-0124-FEDER-028417 POCI-01-0145-FEDER- 007440 info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID/NEU/04539/2013/PT SFRH/ BD/50139/2009 |
Serial title, monograph or event: | Journal of Diabetes Research | Volume: | 2017 | Abstract: | Diabetic nephropathy (DN) is now the single commonest cause of end-stage renal disease (ESRD) worldwide and one of the main causes of death in diabetic patients. It is also acknowledged as an independent risk factor for cardiovascular disease (CVD). Since sitagliptin was approved, many studies have been carried out revealing its ability to not only improve metabolic control but also ameliorate dysfunction in various diabetes-targeted organs, especially the kidney, due to putative underlying cytoprotective properties, namely, its antiapoptotic, antioxidant, anti-inflammatory, and antifibrotic properties. Despite overall recommendations, many patients spend a long time well outside the recommended glycaemic range and, therefore, have an increased risk for developing micro- and macrovascular complications. Currently, it is becoming clearer that type 2 diabetes mellitus (T2DM) management must envision not only the improvement in glycaemic control but also, and particularly, the prevention of pancreatic deterioration and the evolution of complications, such as DN. This review aims to provide an overview of the current knowledge in the field of renoprotective actions of sitagliptin, namely, improvement in diabetic dysmetabolism, hemodynamic factors, renal function, diabetic kidney lesions, and cytoprotective properties. | URI: | https://hdl.handle.net/10316/108226 | ISSN: | 2314-6745 2314-6753 |
DOI: | 10.1155/2017/5164292 | Rights: | openAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais I&D IBILI - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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Renoprotective-Effects-of-the-Dipeptidyl-Peptidase4-Inhibitor-Sitagliptin-A-Review-in-Type-2-DiabetesJournal-of-Diabetes-Research.pdf | 7.68 MB | Adobe PDF | View/Open |
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