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Title: Protective Effect of Green Tea (Camellia sinensis (L.) Kuntze) against Prostate Cancer: From In Vitro Data to Algerian Patients
Authors: Lassed, Somia
Deus, Cláudia M. 
Djebbari, Radja
Zama, Djamila
Oliveira, Paulo J. 
Rizvanov, Albert A. 
Dahdouh, Abderrezak
Benayache, Fadila
Benayache, Samir
Issue Date: 2017
Publisher: Hindawi
Project: PTDC/DTP-FTO/2433/2014 
QREN Project 4832 with Reference CENTRO-07- ST24-FEDER-002008 financed through FEDER 
CNEPRU Project (F00920120093) and MESRS (DGRSDT) 
Programof Competitive Growth of Kazan Federal University and subsidy allocated toKazan FederalUniversity for the state assignment in the sphere of scientific activities 
Serial title, monograph or event: Evidence-based Complementary and Alternative Medicine
Volume: 2017
Abstract: Green tea (GT) has been studied for its effects as antioxidant and cancer-preventive agent. Epidemiological studies showed that GT consumption decreases the risk for prostate cancer (PC). To investigate whether erythrocyte oxidative stress (OS) is associated with PC and whether daily consumption of GT improves the oxidative phenotype, we performed a study in a group of Algerian PC patients, preceded by an in vitro study to characterize composition and antioxidant/antiproliferative activities of the GT used. This contained a high content of phenolic and flavonoid compounds, demonstrating in vitro antioxidant activity and significant antiproliferative effect on human prostate cancer PC-3 cell line. Seventy PC patients and 120 age-matched healthy subjects participated in the study, with glutathione (GSH), malondialdehyde (MDA), and catalase activity evaluated before and after GT consumption. The results showed a reduced GSH and catalase activity and a high level of MDA in erythrocytes from PC patients. The consumption of 2-3 cups per day of GT during 6 months significantly increased GSH concentration and catalase activity and decreased MDA concentration. In conclusion, GT significantly decreased OS in Algerian PC patients. Regular consumption of GT for a long period may prevent men from developing PC or at least delay its progression.
ISSN: 1741-427X
DOI: 10.1155/2017/1691568
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais

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