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https://hdl.handle.net/10316/107504
Título: | Strategies and methodologies for the construction of spiro-γ-lactams: an update | Autor: | Alves, Américo J. S. Alves, Nuno G. Soares, Maria I. L. Pinho e Melo, Teresa M. V. D. |
Palavras-chave: | γ-lactams; spiro-γ-lactams; spiropyrrolinin-2-ones; spirocyclic compounds; spirocyclization | Data: | 2021 | Editora: | Royal Society of Chemistry | Projeto: | UIDB/00313/2020 UIDP/QUI/00313/2020 SFRH/BD/128910/2017 PD/BD/135287/2017 |
Título da revista, periódico, livro ou evento: | Organic Chemistry Frontiers | Volume: | 8 | Número: | 13 | Resumo: | Spiro-γ-lactams (spiropyrrolinin-2-ones) are a class of spirocyclic compounds that are present in a wide range of synthetic bioactive and naturally occurring molecules. The increasing attention to spirocyclic lactams in drug discovery has been accompanied by a growing interest in these compounds from a synthetic point of view, namely as synthetic building blocks in organic chemistry, due to their inherent rigidity and complexity. Herein, an insight into the most relevant advances in the synthesis of the spiro-γ-lactam scaffold since 2015 is provided, addressing issues such as scope, efficiency, selectivity and mechanistic insights. | URI: | https://hdl.handle.net/10316/107504 | ISSN: | 2052-4129 | DOI: | 10.1039/D0QO01564D | Direitos: | embargoedAccess |
Aparece nas coleções: | I&D CQC - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Strategiesand methodologies for_Alves2021OrgChemFront.pdf | 7.22 MB | Adobe PDF | Ver/Abrir |
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