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https://hdl.handle.net/10316/107427
Title: | Applications of Photodynamic Therapy in Endometrial Diseases | Authors: | Correia-Barros, Gabriela Serambeque, Beatriz Carvalho, Maria João Marto, Carlos Miguel Pineiro, Marta Pinho e Melo, Teresa M. V. D. Botelho, M. Filomena Laranjo, Mafalda |
Keywords: | endometrial neoplasms; endometrium; models; animal; photochemotherapy; photodynamic therapy; therapeutics | Issue Date: | 23-May-2022 | Publisher: | MDPI | Project: | This research was funded by the Foundation for Science and Technology (FCT), Portugal, and the European Social Fund (FSE), through a PhD fellowship awarded to Beatriz Serambeque (2020.07672.BD). Project PTDC/QUI-QOR/0103/2021 was financed by FCT, I.P./MCTES, by national funds (PIDDAC). CIBB was supported by National Funds via FCT through the Strategic Projects UID/NEU/04539/2019, UIDB/04539/2020, UIDP/04539/2020, and by COMPETE-FEDER (POCI- 01-0145-FEDER-007440). Coimbra Chemistry Centre (CQC) was supported by FCT under projects UIDB/00313/2020 and UIDP/00313/2020. | Serial title, monograph or event: | Bioengineering | Volume: | 9 | Issue: | 5 | Abstract: | Photodynamic therapy (PDT) is a medical procedure useful for several benign conditions (such as wound healing and infections) and cancer. PDT is minimally invasive, presents few side effects, good scaring, and is able to minimal tissue destruction maintaining organ anatomy and function. Endoscopic access to the uterus puts PDT in the spotlight for endometrial disease treatment. This work systematically reviews the current evidence of PDT's potential and usefulness in endometrial diseases. Thus, this narrative review focused on PDT applications for endometrial disease, including reports regarding in vitro, ex vivo, animal, and clinical studies. Cell lines and primary samples were used as in vitro models of cancer, adenomyosis and endometrioses, while most animal studies focused the PDT outcomes on endometrial ablation. A few clinical attempts are known using PDT for endometrial ablation and cancer lesions. This review emphasises PDT as a promising field of research. This therapeutic approach has the potential to become an effective conservative treatment method for endometrial benign and malignant lesions. Further investigations with improved photosensitisers are highly expected. | URI: | https://hdl.handle.net/10316/107427 | ISSN: | 2306-5354 | DOI: | 10.3390/bioengineering9050226 | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais I&D CQC - Artigos em Revistas Internacionais |
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