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https://hdl.handle.net/10316/107234| Title: | Signaling by adenosine receptors-Homeostatic or allostatic control? | Authors: | Cunha, Rodrigo A. | Issue Date: | Apr-2019 | Publisher: | Public Library of Science | Project: | R.A.C. was supported by Fundacion LaCaixa (HR17-00523), Centro 2020 (CENTRO-01- 0145-FEDER-000008:BrainHealth 2020 and CENTRO-01-0246-FEDER-000010) and FCT (POCI- 01-0145-FEDER-03127). R.A.C. is a scientific consultant to ISIC – Institute for Scientific Information on Coffee. | Serial title, monograph or event: | PLoS Biology | Volume: | 17 | Issue: | 4 | Abstract: | Adenosine modulation is considered both a paracrine signal coordinating different cells in a tissue and a stress signal. Both functions are ensured by 4 types of adenosine receptors (ARs), which have been studied individually. Mice with knockout of all ARs (quad-AR-KO) now allow enquiring the overall function of the adenosine modulation system. The observed "normal" physiology of quad-AR-KO mice indicates that ARs do not regulate homeostasis and are likely recruited to selectively control allostasis. | URI: | https://hdl.handle.net/10316/107234 | ISSN: | 1545-7885 | DOI: | 10.1371/journal.pbio.3000213 | Rights: | openAccess |
| Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
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| Signaling-by-adenosine-receptorsHomeostatic-or-allostatic-controlPLoS-Biology.pdf | 225.07 kB | Adobe PDF | View/Open |
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