Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/107234
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dc.contributor.authorCunha, Rodrigo A.-
dc.date.accessioned2023-06-15T11:11:30Z-
dc.date.available2023-06-15T11:11:30Z-
dc.date.issued2019-04-
dc.identifier.issn1545-7885pt
dc.identifier.urihttps://hdl.handle.net/10316/107234-
dc.description.abstractAdenosine modulation is considered both a paracrine signal coordinating different cells in a tissue and a stress signal. Both functions are ensured by 4 types of adenosine receptors (ARs), which have been studied individually. Mice with knockout of all ARs (quad-AR-KO) now allow enquiring the overall function of the adenosine modulation system. The observed "normal" physiology of quad-AR-KO mice indicates that ARs do not regulate homeostasis and are likely recruited to selectively control allostasis.pt
dc.language.isoengpt
dc.publisherPublic Library of Sciencept
dc.relationR.A.C. was supported by Fundacion LaCaixa (HR17-00523), Centro 2020 (CENTRO-01- 0145-FEDER-000008:BrainHealth 2020 and CENTRO-01-0246-FEDER-000010) and FCT (POCI- 01-0145-FEDER-03127). R.A.C. is a scientific consultant to ISIC – Institute for Scientific Information on Coffee.pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subject.meshAdenosinept
dc.subject.meshAllostasispt
dc.subject.meshAnimalspt
dc.subject.meshHomeostasispt
dc.subject.meshMicept
dc.subject.meshMice, Knockoutpt
dc.subject.meshReceptors, Purinergic P1pt
dc.subject.meshSignal Transductionpt
dc.titleSignaling by adenosine receptors-Homeostatic or allostatic control?pt
dc.typearticle-
degois.publication.firstPagee3000213pt
degois.publication.issue4pt
degois.publication.titlePLoS Biologypt
dc.peerreviewedyespt
dc.identifier.doi10.1371/journal.pbio.3000213pt
degois.publication.volume17pt
dc.date.embargo2019-04-01*
uc.date.periodoEmbargo0pt
item.grantfulltextopen-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairetypearticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextCom Texto completo-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0003-2550-6422-
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
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