Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/107037
Título: | Murine Models of Acute Pancreatitis: A Critical Appraisal of Clinical Relevance | Autor: | Silva-Vaz, Pedro Abrantes, Ana Margarida Gouveia, António Botelho, Maria Filomena Tralhão, José Guilherme Castelo-Branco, Miguel |
Palavras-chave: | acute pancreatitis; animalmodels; murine; experimentalmodels; biomarkers; inflammation | Data: | 7-Jun-2019 | Editora: | MDPI | Projeto: | PEst-C/SAU/UI3282/2013 info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID/NEU/04539/2013/PT |
Título da revista, periódico, livro ou evento: | International Journal of Molecular Sciences | Volume: | 20 | Número: | 11 | Resumo: | Acute pancreatitis (AP) is a severe disease associated with high morbidity and mortality. Clinical studies can provide some data concerning the etiology, pathophysiology, and outcomes of this disease. However, the study of early events and new targeted therapies cannot be performed on humans due to ethical reasons. Experimental murine models can be used in the understanding of the pancreatic inflammation, because they are able to closely mimic the main features of human AP, namely their histologic glandular changes and distant organ failure. These models continue to be important research tools for the reproduction of the etiological, environmental, and genetic factors associated with the pathogenesis of this inflammatory pathology and the exploration of novel therapeutic options. This review provides an overview of several murine models of AP. Furthermore, special focus is made on the most frequently carried out models, the protocols used, and their advantages and limitations. Finally, examples are provided of the use of these models to improve knowledge of the mechanisms involved in the pathogenesis, identify new biomarkers of severity, and develop new targeted therapies. | URI: | https://hdl.handle.net/10316/107037 | ISSN: | 1422-0067 | DOI: | 10.3390/ijms20112794 | Direitos: | openAccess |
Aparece nas coleções: | I&D ICBR - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais I&D IBILI - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Murine-models-of-acute-pancreatitis-A-critical-appraisal-of-clinical-relevanceInternational-Journal-of-Molecular-Sciences.pdf | 1.35 MB | Adobe PDF | Ver/Abrir |
Citações SCOPUSTM
27
Visto em 7/out/2024
Citações WEB OF SCIENCETM
23
Visto em 2/out/2024
Visualizações de página
94
Visto em 2/out/2024
Downloads
27
Visto em 2/out/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Este registo está protegido por Licença Creative Commons