Utilize este identificador para referenciar este registo: https://hdl.handle.net/10316/106811
Título: Chemistry and Pharmacology of the Kazakh Crataegus Almaatensis Pojark: An Asian Herbal Medicine
Autor: Soares, Sabrina 
Bekbolatova, Elmira
Cotrim, Maria Dulce 
Sakipova, Zuriyadda
Ibragimova, Liliya
Kukula-Koch, Wirginia
Giorno, Thais B. Sardella
Fernandes, Patrícia D.
Fonseca, Diogo André 
Boylan, Fabio 
Palavras-chave: Crataegus almaatensis Pojark; Kazakhstan; HSCCC; Flavonoids; vascular activity; anti-inflammatory activity
Data: 10-Ago-2019
Editora: MDPI
Projeto: F.B. wishes to acknowledge the High Education Authority’s Programme for Research in Third-Level Institutions Cycle 5’s funding support for T.B.S.I.; P.D.F. also acknowledges the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, grant support and fellowship), Fundacão Carlos Chagas Filho de Apoio à Pesquisa do Estado do Rio de Janeiro (FAPERJ, grant support to PDF), and Conselho de Administracão de Pessoal de Ensino Superior (CAPES). 
Título da revista, periódico, livro ou evento: Antioxidants
Volume: 8
Número: 8
Resumo: Crataegus almaatensis, an endemic ornamental plant in Kazakhstan is used in popular medicine due to its cardiotonic properties. The most studied species of the same genus are commonly found in Europe, which shows the importance of having the Kazakh species validated via its chemical and pharmacological studies. High-speed countercurrent chromatography (HSCCC) operated under optimized conditions enabled an isolation of the three main compounds from the aqueous phase of the leaves ethanol extract, further identified by nuclear magnetic resonance (NMR), as quercetin 3-O-rhamnoside (quercitrin) (4.02% of the crude extract-CECa); quercetin 3-O-β-galactoside (hyperoside) (1.82% of CECa); kaempferol 3-O-α-L-rhamnoside (afzelin) (0.94% of CECa). The CECa, the aqueous phase of the crude extract (APCa) together with the isolates were evaluated for their vascular (vascular reactivity in human internal mammary artery-HIMA), anti-nociceptive (formalin-induced liking response and hot plate) and anti-inflammatory (subcutaneous air-pouch model-SAP) activities. CECa at the concentrations of 0.014 and 0.14 mg/mL significantly increased the maximum contractility response of HIMA to noradrenaline. The APCa CR curve (0.007-0.7 mg/mL) showed an intrinsic relaxation effect of the HIMA. APCa at the dose of 100 mg/kg i.p. significantly decreased the total leukocyte count and the IL-1β release in the SAP wash.
URI: https://hdl.handle.net/10316/106811
ISSN: 2076-3921
DOI: 10.3390/antiox8080300
Direitos: openAccess
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