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Title: | Crescent-Like Lesions as an Early Signature of Nephropathy in a Rat Model of Prediabetes Induced by a Hypercaloric Diet | Authors: | Nunes, Sara Alves, André Preguiça, Inês Barbosa, Adelaide Vieira, Pedro Mendes, Fernando Martins, Diana Viana, Sofia D. Reis, Flávio |
Keywords: | prediabetes; nephropathy; rat model; diet-induced; renal lipidosis; glomerular crescent-like lesions | Issue Date: | 25-Mar-2020 | Publisher: | MDPI | Project: | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID/NEU/04539/2013/PT info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID/NEU/04539/2019/PT UIDB/04539/2020 UIDP/04539/2020 info:eu-repo/grantAgreement/SFRH/BD/109017/2015 PTDC/SAU-NUT/31712/2017 CENTRO-01-0145-FEDER-000012/HealthyAging2020 |
Serial title, monograph or event: | Nutrients | Volume: | 12 | Issue: | 4 | Abstract: | Diabetic nephropathy (DN) is a major microvascular complication of diabetes. Obesity and hyperlipidemia, fueled by unhealthy food habits, are risk factors to glomerular filtration rate (GFR) decline and DN progression. Several studies recommend that diabetic patients should be screened early (in prediabetes) for kidney disease, in order to prevent advanced stages, for whom the current interventions are clearly inefficient. This ambition greatly depends on the existence of accurate early biomarkers and novel molecular targets, which only may arise with a more thorough knowledge of disease pathophysiology. We used a rat model of prediabetes induced by 23 weeks of high-sugar/high-fat (HSuHF) diet to characterize the phenotype of early renal dysfunction and injury. When compared with the control animals, HSuHF-treated rats displayed a metabolic phenotype compatible with obese prediabetes, displaying impaired glucose tolerance and insulin sensitivity, along with hypertriglyceridemia, and lipid peroxidation. Despite unchanged creatinine levels, the prediabetic animals presented glomerular crescent-like lesions, accompanied by increased kidney Oil-Red-O staining, triglycerides content and mRNA expression of IL-6 and iNOS. This model of HSuHF-induced prediabetes can be a useful tool to study early features of DN, namely crescent-like lesions, an early signature that deserves in-depth elucidation. | URI: | https://hdl.handle.net/10316/106519 | ISSN: | 2072-6643 | DOI: | 10.3390/nu12040881 | Rights: | openAccess |
Appears in Collections: | I&D ICBR - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais |
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