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https://hdl.handle.net/10316/106486
Título: | Synthesis of Iron(II)-N-Heterocyclic Carbene Complexes: Paving the Way for a New Class of Antibiotics | Autor: | Vinagreiro, Carolina dos Santos Lopes, Rita Royo, Beatriz Silva, Gabriela Jorge da Pereira, Mariette M. |
Palavras-chave: | N-heterocyclic carbene; iron(II)-NHC complexes; antibacterial activity | Data: | 24-Jun-2020 | Editora: | MDPI | Projeto: | UIDB/00313/2020 PTDC/QUI-OUT/27996/2017 LISBOA-01-0145-FEDER-007660 UID/Multi/04551/2013 |
Título da revista, periódico, livro ou evento: | Molecules | Volume: | 25 | Número: | 12 | Resumo: | The synthesis and structural modulation of five pro-ligand salts was achieved using alternative sustainable synthetic strategies, the use of microwaves being the method of choice, with an 81% yield and an E factor of 43 for 3d. After complexation with Fe3(CO)12 by direct reaction with the appropriate pro-ligands at 130 °C, a set of iron(II) N-heterocyclic carbene (NHC) complexes were isolated and fully characterized (via 1H and 13C NMR and IR spectroscopy and elemental analysis). The antibacterial activities of the iron(II)-NHC complexes were tested against standard World Health Organization priority bacterial strains: Staphylococcus aureus ATCC 29213 and Escherichia coli ATCC 25922. The results showed a significant effect of the Fe(II)-NHC side-chain on the antibacterial activity against both Gram-negative and Gram-positive bacteria. Among all compounds, the most lipophilic iron complex, 3b, was found to be the most active one, with a minimum inhibitory concentration of 8 µg/mL. Pioneering mechanistic studies suggested an alternative mechanism of action (OH· formation), which opens the way for the development of a new class of antibiotics. | URI: | https://hdl.handle.net/10316/106486 | ISSN: | 1420-3049 | DOI: | 10.3390/molecules25122917 | Direitos: | openAccess |
Aparece nas coleções: | I&D CQC - Artigos em Revistas Internacionais FFUC- Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
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Synthesis-of-ironIINheterocyclic-carbene-complexes-Paving-the-way-for-a-new-class-of-antibioticsMolecules.pdf | 2.46 MB | Adobe PDF | Ver/Abrir |
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