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Title: | Mechanistic Actions of microRNAs in Diabetic Wound Healing | Authors: | Petkovic, Marija Sørensen, Anja Elaine Leal, Ermelindo Carreira Carvalho, Eugenia Dalgaard, Louise Torp |
Keywords: | diabetic wound healing; chronic wounds; inflammation; proliferation; remodeling; tissue and circulating microRNAs; tissue regeneration | Issue Date: | 2-Oct-2020 | Publisher: | MDPI | Project: | Danish Diabetes Academy (DDA) supported by the Novo Nordisk Foundation and from Roskilde University POCI-01-0145-FEDER-007440 UIDB/04539/2020 Healthy Aging 2020-CENTRO-01-0145-FEDER-000012-N2323 DL57/2016/CP1448/CT0024, NIGMS-P20GM109096, 5P30-AG028718 |
Serial title, monograph or event: | Cells | Volume: | 9 | Issue: | 10 | Abstract: | Wound healing is a complex biological process that is impaired under diabetes conditions. Chronic non-healing wounds in diabetes are some of the most expensive healthcare expenditures worldwide. Early diagnosis and efficacious treatment strategies are needed. microRNAs (miRNAs), a class of 18-25 nucleotide long RNAs, are important regulatory molecules involved in gene expression regulation and in the repression of translation, controlling protein expression in health and disease. Recently, miRNAs have emerged as critical players in impaired wound healing and could be targets for potential therapies for non-healing wounds. Here, we review and discuss the mechanistic background of miRNA actions in chronic wounds that can shed the light on their utilization as specific wound healing biomarkers. | URI: | https://hdl.handle.net/10316/105858 | ISSN: | 2073-4409 | DOI: | 10.3390/cells9102228 | Rights: | openAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais IIIUC - Artigos em Revistas Internacionais |
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Mechanistic-Actions-of-microRNAs-in-Diabetic-Wound-HealingCells.pdf | 36.74 MB | Adobe PDF | View/Open |
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