Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/105858
Title: Mechanistic Actions of microRNAs in Diabetic Wound Healing
Authors: Petkovic, Marija 
Sørensen, Anja Elaine
Leal, Ermelindo Carreira 
Carvalho, Eugenia 
Dalgaard, Louise Torp
Keywords: diabetic wound healing; chronic wounds; inflammation; proliferation; remodeling; tissue and circulating microRNAs; tissue regeneration
Issue Date: 2-Oct-2020
Publisher: MDPI
Project: Danish Diabetes Academy (DDA) supported by the Novo Nordisk Foundation and from Roskilde University 
POCI-01-0145-FEDER-007440 
UIDB/04539/2020 
Healthy Aging 2020-CENTRO-01-0145-FEDER-000012-N2323 
DL57/2016/CP1448/CT0024, NIGMS-P20GM109096, 5P30-AG028718 
Serial title, monograph or event: Cells
Volume: 9
Issue: 10
Abstract: Wound healing is a complex biological process that is impaired under diabetes conditions. Chronic non-healing wounds in diabetes are some of the most expensive healthcare expenditures worldwide. Early diagnosis and efficacious treatment strategies are needed. microRNAs (miRNAs), a class of 18-25 nucleotide long RNAs, are important regulatory molecules involved in gene expression regulation and in the repression of translation, controlling protein expression in health and disease. Recently, miRNAs have emerged as critical players in impaired wound healing and could be targets for potential therapies for non-healing wounds. Here, we review and discuss the mechanistic background of miRNA actions in chronic wounds that can shed the light on their utilization as specific wound healing biomarkers.
URI: https://hdl.handle.net/10316/105858
ISSN: 2073-4409
DOI: 10.3390/cells9102228
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
IIIUC - Artigos em Revistas Internacionais

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