Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/105447
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Fernandes, Mara Yone D. | - |
dc.contributor.author | Dobrachinski, Fernando | - |
dc.contributor.author | Silva, Henrique B. | - |
dc.contributor.author | Lopes, João Pedro | - |
dc.contributor.author | Gonçalves, Francisco Q. | - |
dc.contributor.author | Soares, Felix A A | - |
dc.contributor.author | Porciúncula, Lisiane O. | - |
dc.contributor.author | Andrade, Geanne M | - |
dc.contributor.author | Cunha, Rodrigo A. | - |
dc.contributor.author | Tomé, Ângelo R. | - |
dc.date.accessioned | 2023-02-28T11:48:15Z | - |
dc.date.available | 2023-02-28T11:48:15Z | - |
dc.date.issued | 2021-05-18 | - |
dc.identifier.issn | 2045-2322 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/105447 | - |
dc.description.abstract | The increased healthspan afforded by coffee intake provides novel opportunities to identify new therapeutic strategies. Caffeine has been proposed to afford benefits through adenosine A2A receptors, which can control synaptic dysfunction underlying some brain disease. However, decaffeinated coffee and other main components of coffee such as chlorogenic acids, also attenuate brain dysfunction, although it is unknown if they control synaptic function. We now used electrophysiological recordings in mouse hippocampal slices to test if realistic concentrations of chlorogenic acids directly affect synaptic transmission and plasticity. 3-(3,4-dihydroxycinnamoyl)quinic acid (CA, 1-10 μM) and 5-O-(trans-3,4-dihydroxycinnamoyl)-D-quinic acid (NCA, 1-10 μM) were devoid of effect on synaptic transmission, paired-pulse facilitation or long-term potentiation (LTP) and long-term depression (LTD) in Schaffer collaterals-CA1 pyramidal synapses. However, CA and NCA increased the recovery of synaptic transmission upon re-oxygenation following 7 min of oxygen/glucose deprivation, an in vitro ischemia model. Also, CA and NCA attenuated the shift of LTD into LTP observed in hippocampal slices from animals with hippocampal-dependent memory deterioration after exposure to β-amyloid 1-42 (2 nmol, icv), in the context of Alzheimer's disease. These findings show that chlorogenic acids do not directly affect synaptic transmission and plasticity but can indirectly affect other cellular targets to correct synaptic dysfunction. Unraveling the molecular mechanisms of action of chlorogenic acids will allow the design of hitherto unrecognized novel neuroprotective strategies. | pt |
dc.language.iso | eng | pt |
dc.publisher | Springer Nature | pt |
dc.relation | La Caixa Foundation (LCF/PR/HP17/52190001), | pt |
dc.relation | CENTRO-01-0145-FEDER- 000008:BrainHealth 2020 | pt |
dc.relation | CENTRO-01-0246-FEDER-000010 | pt |
dc.relation | POCI-01-0145-FEDER-03127 | pt |
dc.relation | UIDB/04539/2020 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject.mesh | Alzheimer Disease | pt |
dc.subject.mesh | Animals | pt |
dc.subject.mesh | Chlorogenic Acid | pt |
dc.subject.mesh | Disease Models, Animal | pt |
dc.subject.mesh | Hippocampus | pt |
dc.subject.mesh | In Vitro Techniques | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Mice | pt |
dc.subject.mesh | Mice, Inbred C57BL | pt |
dc.subject.mesh | Neuronal Plasticity | pt |
dc.subject.mesh | Neuroprotective Agents | pt |
dc.subject.mesh | Neurotransmitter Agents | pt |
dc.subject.mesh | Synaptic Transmission | pt |
dc.title | Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices | pt |
dc.type | article | - |
degois.publication.firstPage | 10488 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | Scientific Reports | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1038/s41598-021-89964-0 | pt |
degois.publication.volume | 11 | pt |
dc.date.embargo | 2021-05-18 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-7234-3411 | - |
crisitem.author.orcid | 0000-0002-5122-1802 | - |
crisitem.author.orcid | 0000-0001-8042-0221 | - |
crisitem.author.orcid | 0000-0003-2550-6422 | - |
crisitem.author.orcid | 0000-0001-8671-989X | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Neuromodulation-and-neuroprotective-effects-of-chlorogenic-acids-in-excitatory-synapses-of-mouse-hippocampal-slicesScientific-Reports.pdf | 5.03 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
24
checked on Apr 29, 2024
WEB OF SCIENCETM
Citations
23
checked on May 2, 2024
Page view(s)
67
checked on May 7, 2024
Download(s)
20
checked on May 7, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License