Utilize este identificador para referenciar este registo: https://hdl.handle.net/10316/105329
Título: Naringenin Nano-Delivery Systems and Their Therapeutic Applications
Autor: Bhia, Mohammed
Motallebi, Mahzad
Abadi, Banafshe
Zarepour, Atefeh
Silva, Miguel Pereira da 
Saremnejad, Farinaz
Santos, Ana Cláudia 
Zarrabi, Ali
Melero, Ana
Jafari, Seid Mahdi
Shakibaei, Mehdi
Palavras-chave: naringenin; nutraceuticals; antioxidants; natural products; nanoparticles; drug delivery; nanomedicine; bioavailability; flavonoid
Data: 23-Fev-2021
Editora: MDPI
Projeto: University of Valencia and the Valencian Government (grant numbers UV-19-INV_AE19 and GV2015-054) 
Título da revista, periódico, livro ou evento: Pharmaceutics
Volume: 13
Número: 2
Resumo: Naringenin (NRG) is a polyphenolic phytochemical belonging to the class of flavanones and is widely distributed in citrus fruits and some other fruits such as bergamot, tomatoes, cocoa, and cherries. NRG presents several interesting pharmacological properties, such as anti-cancer, anti-oxidant, and anti-inflammatory activities. However, the therapeutic potential of NRG is hampered due to its hydrophobic nature, which leads to poor bioavailability. Here, we review a wide range of nanocarriers that have been used as delivery systems for NRG, including polymeric nanoparticles, micelles, liposomes, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), nanosuspensions, and nanoemulsions. These nanomedicine formulations of NRG have been applied as a potential treatment for several diseases, using a wide range of in vitro, ex vivo, and in vivo models and different routes of administration. From this review, it can be concluded that NRG is a potential therapeutic option for the treatment of various diseases such as cancer, neurological disorders, liver diseases, ocular disorders, inflammatory diseases, skin diseases, and diabetes when formulated in the appropriate nanocarriers.
URI: https://hdl.handle.net/10316/105329
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics13020291
Direitos: openAccess
Aparece nas coleções:FFUC- Artigos em Revistas Internacionais

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