Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/105304
Title: Blueberry Counteracts Prediabetes in a Hypercaloric Diet-Induced Rat Model and Rescues Hepatic Mitochondrial Bioenergetics
Authors: Nunes, Sara 
Viana, Sofia D. 
Preguiça, Inês 
Alves, André 
Fernandes, Rosa 
Teodoro, João S. 
Matos, Patrícia 
Figueirinha, Artur 
Salgueiro, Lígia 
André, Alexandra
Silva, Sara
Jarak, Ivana 
Carvalho, Rui A. 
Cavadas, Cláudia 
Rolo, Anabela P. 
Palmeira, Carlos M. 
Pintado, Maria M.
Reis, Flávio 
Keywords: blueberries; hypercaloric diet-induced prediabetes; gut microbiota; hepatic energy metabolism; mitochondria function; hepatoprotection
Issue Date: 23-Nov-2021
Publisher: MDPI
Project: UID/NEU/04539/2013 
UID/NEU/04539/2019 
UIDB/04539/2020 
UIDB/50006/2020 
UIDP/04539/2020 
info:eu-repo/grantAgreement/SFRH/BD/109017/2015 
PTDC/SAU-NUT/31712/2017 
POCI-01-0145-FEDER- 007440 
POCI-01-0145-FEDER-031712 
CEECIND/04400/2017 
REEQ/481/QUI/2006 
RECI/QEQ-QFI/0168/2012 
CENTRO-07-CT62-FEDER-002012 
Serial title, monograph or event: Nutrients
Volume: 13
Issue: 12
Abstract: The paramount importance of a healthy diet in the prevention of type 2 diabetes is now well recognized. Blueberries (BBs) have been described as attractive functional fruits for this purpose. This study aimed to elucidate the cellular and molecular mechanisms pertaining to the protective impact of blueberry juice (BJ) on prediabetes. Using a hypercaloric diet-induced prediabetic rat model, we evaluated the effects of BJ on glucose, insulin, and lipid profiles; gut microbiota composition; intestinal barrier integrity; and metabolic endotoxemia, as well as on hepatic metabolic surrogates, including several related to mitochondria bioenergetics. BJ supplementation for 14 weeks counteracted diet-evoked metabolic deregulation, improving glucose tolerance, insulin sensitivity, and hypertriglyceridemia, along with systemic and hepatic antioxidant properties, without a significant impact on the gut microbiota composition and related mechanisms. In addition, BJ treatment effectively alleviated hepatic steatosis and mitochondrial dysfunction observed in the prediabetic animals, as suggested by the amelioration of bioenergetics parameters and key targets of inflammation, insulin signaling, ketogenesis, and fatty acids oxidation. In conclusion, the beneficial metabolic impact of BJ in prediabetes may be mainly explained by the rescue of hepatic mitochondrial bioenergetics. These findings pave the way to support the use of BJ in prediabetes to prevent diabetes and its complications.
URI: https://hdl.handle.net/10316/105304
ISSN: 2072-6643
DOI: 10.3390/nu13124192
Rights: openAccess
Appears in Collections:I&D ICBR - Artigos em Revistas Internacionais
I&D CIBB - Artigos em Revistas Internacionais
FCTUC Ciências da Vida - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais
FFUC- Artigos em Revistas Internacionais
I&D CIEPQPF - Artigos em Revistas Internacionais

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