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Título: | Highlights on Steroidal Arylidene Derivatives as a Source of Pharmacologically Active Compounds: A Review | Autor: | Brito, Vanessa Alves, Gilberto Almeida, Paulo Silvestre, Samuel |
Palavras-chave: | steroids; arylidenesteroids; aldol condensation; bioactivity; heterocycles | Data: | 2-Abr-2021 | Editora: | MDPI | Projeto: | FEDER funds through the POCI-COMPETE 2020-Operational Programme Competitiveness and Internationalization in Axis I-Strengthening Research, Technological Development and Innovation (Project No. 007491) UID/ Multi/00709 grant SFRH/BD/131059/2017 C4-Cloud Computing Competences Center project (CENTRO-01-0145-FEDER-000019) |
Título da revista, periódico, livro ou evento: | Molecules | Volume: | 26 | Número: | 7 | Resumo: | Steroids constitute a unique class of chemical compounds, playing an important role in physiopathological processes, and have high pharmacological interest. Additionally, steroids have been associated with a relatively low toxicity and high bioavailability. Nowadays, multiple steroidal derivatives are clinically available for the treatment of numerous diseases. Moreover, different structural modifications on their skeleton have been explored, aiming to develop compounds with new and improved pharmacological properties. Thus, steroidal arylidene derivatives emerged as a relevant example of these modifications. This family of compounds has been mainly described as 17β-hydroxysteroid dehydrogenase type 1 and aromatase inhibitors, as well as neuroprotective and anticancer agents. Besides, due to their straightforward preparation and intrinsic chemical reactivity, steroidal arylidene derivatives are important synthetic intermediates for the preparation of other compounds, particularly bearing heterocyclic systems. In fact, starting from arylidenesteroids, it was possible to develop bioactive steroidal pyrazolines, pyrazoles, pyrimidines, pyridines, spiro-pyrrolidines, amongst others. Most of these products have also been studied as anti-inflammatory and anticancer agents, as well as 5α-reductase and aromatase inhibitors. This work aims to provide a comprehensive overview of steroidal arylidene derivatives described in the literature, highlighting their bioactivities and importance as synthetic intermediates for other pharmacologically active compounds. | URI: | https://hdl.handle.net/10316/105261 | ISSN: | 1420-3049 | DOI: | 10.3390/molecules26072032 | Direitos: | openAccess |
Aparece nas coleções: | I&D CNC - Artigos em Revistas Internacionais |
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Highlights-on-steroidal-arylidene-derivatives-as-a-source-of-pharmacologically-active-compounds-A-reviewMolecules.pdf | 4.04 MB | Adobe PDF | Ver/Abrir |
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