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Title: Parental Risk Factors and Child Birth Data in a Matched Year and Sex Group Cleft Population: A Case-Control Study
Authors: Francisco, Inês 
Caramelo, Francisco 
Fernandes, Maria Helena
Vale, Francisco 
Keywords: cleft palate; cleft lip; environmental risk factors; parental age; body mass index; child birth data
Issue Date: 27-Apr-2021
Publisher: MDPI
Serial title, monograph or event: International Journal of Environmental Research and Public Health
Volume: 18
Issue: 9
Abstract: (1) Background: The etiology of orofacial cleft (OC) is not completely known but several genetic and environmental risk factors have been identified. Moreover, a knowledge gap still persists regarding neonatal characteristics. This study evaluated the effect of parental age and mothers' body mass index on the risk of having an OC child, in a matched year and sex group (cleft/healthy control). Additionally, birth data were analyzed between groups. (2) Methods: 266 individuals born between 1995 to 2015 were evaluated: 133 OC individuals (85 males/48 females) and 133 control (85 males/48 females). A logistic model was used for the independent variables. ANOVA or Kruskal-Wallis tests were used for comparison between the OC phenotypes. (3) Results: Regarding statistically significant parental related factors, the probability of having a cleft child decreases for each maternal year increase (odds ratio = 0.903) and increases for each body mass index unit (kg/m2) increase (odds ratio = 1.14). On the child data birth, for each mass unit (kg) increase, the probability of having a cleft child decrease (odds ratio = 0.435). (4) Conclusions: In this study, only maternal body mass index and maternal age found statistical differences in the risk of having a cleft child. In the children's initial data, the cleft group found a higher risk of having a lower birth weight but no relation was found regarding length and head circumference.
ISSN: 1660-4601
DOI: 10.3390/ijerph18094615
Rights: openAccess
Appears in Collections:FMUC Med. Dentária - Artigos em Revistas Internacionais
I&D ICBR - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais

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