Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/104740
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Francisco, Inês | - |
dc.contributor.author | Caramelo, Francisco | - |
dc.contributor.author | Fernandes, Maria Helena | - |
dc.contributor.author | Vale, Francisco | - |
dc.date.accessioned | 2023-01-24T09:05:38Z | - |
dc.date.available | 2023-01-24T09:05:38Z | - |
dc.date.issued | 2021-04-27 | - |
dc.identifier.issn | 1660-4601 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/104740 | - |
dc.description.abstract | (1) Background: The etiology of orofacial cleft (OC) is not completely known but several genetic and environmental risk factors have been identified. Moreover, a knowledge gap still persists regarding neonatal characteristics. This study evaluated the effect of parental age and mothers' body mass index on the risk of having an OC child, in a matched year and sex group (cleft/healthy control). Additionally, birth data were analyzed between groups. (2) Methods: 266 individuals born between 1995 to 2015 were evaluated: 133 OC individuals (85 males/48 females) and 133 control (85 males/48 females). A logistic model was used for the independent variables. ANOVA or Kruskal-Wallis tests were used for comparison between the OC phenotypes. (3) Results: Regarding statistically significant parental related factors, the probability of having a cleft child decreases for each maternal year increase (odds ratio = 0.903) and increases for each body mass index unit (kg/m2) increase (odds ratio = 1.14). On the child data birth, for each mass unit (kg) increase, the probability of having a cleft child decrease (odds ratio = 0.435). (4) Conclusions: In this study, only maternal body mass index and maternal age found statistical differences in the risk of having a cleft child. In the children's initial data, the cleft group found a higher risk of having a lower birth weight but no relation was found regarding length and head circumference. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | cleft palate | pt |
dc.subject | cleft lip | pt |
dc.subject | environmental risk factors | pt |
dc.subject | parental age | pt |
dc.subject | body mass index | pt |
dc.subject | child birth data | pt |
dc.subject.mesh | Case-Control Studies | pt |
dc.subject.mesh | Child | pt |
dc.subject.mesh | Female | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Infant, Newborn | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Parturition | pt |
dc.subject.mesh | Pregnancy | pt |
dc.subject.mesh | Risk Factors | pt |
dc.subject.mesh | Cleft Lip | pt |
dc.subject.mesh | Cleft Palate | pt |
dc.title | Parental Risk Factors and Child Birth Data in a Matched Year and Sex Group Cleft Population: A Case-Control Study | pt |
dc.type | article | - |
degois.publication.firstPage | 4615 | pt |
degois.publication.issue | 9 | pt |
degois.publication.title | International Journal of Environmental Research and Public Health | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/ijerph18094615 | pt |
degois.publication.volume | 18 | pt |
dc.date.embargo | 2021-04-27 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.orcid | 0000-0002-3283-5104 | - |
crisitem.author.orcid | 0000-0002-0015-8604 | - |
crisitem.author.orcid | 0000-0003-2615-2929 | - |
Appears in Collections: | FMUC Med. Dentária - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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