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https://hdl.handle.net/10316/10384| Title: | Solubility of Flurbiprofen in Supercritical Carbon Dioxide | Authors: | Duarte, Ana Rita C. Coimbra, Patrícia Sousa, Hermínio C. de Duarte, Catarina M. M. |
Issue Date: | 13-May-2004 | Publisher: | American Chemical Society | Citation: | Journal of Chemical & Engineering Data. 49:3 (2004) 449-452 | Abstract: | Equilibrium solubility of flurbiprofen, a nonsteroidal antiinflammatory agent, in supercritical carbon dioxide was measured by a static analytical method in the pressure range from (8.0 to 25.0) MPa, at temperatures of (303.0, 313.0, and 323.0) K. The cosolvent effect of ethanol in the solubility of the bioactive compound in supercritical carbon dioxide was investigated at 18 MPa and 313 K. The results obtained have a potential application in supercritical processes for this drug. Experimental solubility data were correlated with an empirical density-based Chrastil model. | URI: | https://hdl.handle.net/10316/10384 | ISSN: | 0021-9568 | DOI: | 10.1021/je034099b | Rights: | openAccess |
| Appears in Collections: | FCTUC Eng.Química - Artigos em Revistas Internacionais |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Solubility of Flurbiprofen in Supercritical Carbon Dioxide.pdf | 55.31 kB | Adobe PDF | View/Open |
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