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Title: Proof-of-Concept Study of Multifunctional Hybrid Nanoparticle System Combined with NIR Laser Irradiation for the Treatment of Melanoma
Authors: Lopes, Joana
Ferreira-Gonçalves, Tânia
Figueiredo, Isabel V. 
Rodrigues, Cecília M. P.
Ferreira, Hugo
Ferreira, David 
Viana, Ana S.
Faísca, Pedro
Gaspar, Maria Manuela
Coelho, João M. P.
Silva, Catarina Oliveira
Reis, Catarina Pinto 
Keywords: multifunctional nanoparticles; gold nanoparticles; targeted therapy; photothermal therapy; superficial tumors; melanoma; experimental models
Issue Date: 30-Mar-2021
Publisher: MDPI AG
Project: PTDC/BBB-BMC/0611/2012 
Serial title, monograph or event: Biomolecules
Volume: 11
Issue: 4
Abstract: The global impact of cancer emphasizes the importance of developing innovative, effective and minimally invasive therapies. In the context of superficial cancers, the development of a multifunctional nanoparticle-based system and its in vitro and in vivo safety and efficacy characterization are, herein, proposed as a proof-of-concept. This multifunctional system consists of gold nanoparticles coated with hyaluronic and oleic acids, and functionalized with epidermal growth factor for greater specificity towards cutaneous melanoma cells. This nanoparticle system is activated by a near-infrared laser. The characterization of this nanoparticle system included several phases, with in vitro assays being firstly performed to assess the safety of gold nanoparticles without laser irradiation. Then, hairless immunocompromised mice were selected for a xenograft model upon inoculation of A375 human melanoma cells. Treatment with near-infrared laser irradiation for five minutes combined with in situ administration of the nanoparticles showed a tumor volume reduction of approximately 80% and, in some cases, led to the formation of several necrotic foci, observed histologically. No significant skin erythema at the irradiation zone was verified, nor other harmful effects on the excised organs. In conclusion, these assays suggest that this system is safe and shows promising results for the treatment of superficial melanoma.
ISSN: 2218-273X
DOI: 10.3390/biom11040511
Rights: openAccess
Appears in Collections:I&D ICBR - Artigos em Revistas Internacionais
FFUC- Artigos em Revistas Internacionais

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