Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/103765
DC FieldValueLanguage
dc.contributor.authorLopes, Joana-
dc.contributor.authorFerreira-Gonçalves, Tânia-
dc.contributor.authorFigueiredo, Isabel V.-
dc.contributor.authorRodrigues, Cecília M. P.-
dc.contributor.authorFerreira, Hugo-
dc.contributor.authorFerreira, David-
dc.contributor.authorViana, Ana S.-
dc.contributor.authorFaísca, Pedro-
dc.contributor.authorGaspar, Maria Manuela-
dc.contributor.authorCoelho, João M. P.-
dc.contributor.authorSilva, Catarina Oliveira-
dc.contributor.authorReis, Catarina Pinto-
dc.date.accessioned2022-11-25T11:22:51Z-
dc.date.available2022-11-25T11:22:51Z-
dc.date.issued2021-03-30-
dc.identifier.issn2218-273Xpt
dc.identifier.urihttps://hdl.handle.net/10316/103765-
dc.description.abstractThe global impact of cancer emphasizes the importance of developing innovative, effective and minimally invasive therapies. In the context of superficial cancers, the development of a multifunctional nanoparticle-based system and its in vitro and in vivo safety and efficacy characterization are, herein, proposed as a proof-of-concept. This multifunctional system consists of gold nanoparticles coated with hyaluronic and oleic acids, and functionalized with epidermal growth factor for greater specificity towards cutaneous melanoma cells. This nanoparticle system is activated by a near-infrared laser. The characterization of this nanoparticle system included several phases, with in vitro assays being firstly performed to assess the safety of gold nanoparticles without laser irradiation. Then, hairless immunocompromised mice were selected for a xenograft model upon inoculation of A375 human melanoma cells. Treatment with near-infrared laser irradiation for five minutes combined with in situ administration of the nanoparticles showed a tumor volume reduction of approximately 80% and, in some cases, led to the formation of several necrotic foci, observed histologically. No significant skin erythema at the irradiation zone was verified, nor other harmful effects on the excised organs. In conclusion, these assays suggest that this system is safe and shows promising results for the treatment of superficial melanoma.pt
dc.language.isoengpt
dc.publisherMDPI AGpt
dc.relationPTDC/BBB-BMC/0611/2012pt
dc.relationUIDB/00645/2020pt
dc.relationUIDB/04138/2020pt
dc.relationUIDP/04138/2020pt
dc.relationSFRH/BD/148044/2019pt
dc.relationSFRH/BD/147306/2019pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subjectmultifunctional nanoparticlespt
dc.subjectgold nanoparticlespt
dc.subjecttargeted therapypt
dc.subjectphotothermal therapypt
dc.subjectsuperficial tumorspt
dc.subjectmelanomapt
dc.subjectexperimental modelspt
dc.subject.meshAnimalspt
dc.subject.meshCell Line, Tumorpt
dc.subject.meshEpidermal Growth Factorpt
dc.subject.meshGoldpt
dc.subject.meshHumanspt
dc.subject.meshLow-Level Light Therapypt
dc.subject.meshMalept
dc.subject.meshMelanomapt
dc.subject.meshMetal Nanoparticlespt
dc.subject.meshMice, SCIDpt
dc.subject.meshMultifunctional Nanoparticlespt
dc.subject.meshOleic Acidpt
dc.subject.meshProof of Concept Studypt
dc.subject.meshSkin Neoplasmspt
dc.subject.meshXenograft Model Antitumor Assayspt
dc.titleProof-of-Concept Study of Multifunctional Hybrid Nanoparticle System Combined with NIR Laser Irradiation for the Treatment of Melanomapt
dc.typearticle-
degois.publication.firstPage511pt
degois.publication.issue4pt
degois.publication.titleBiomoleculespt
dc.peerreviewedyespt
dc.identifier.doi10.3390/biom11040511pt
degois.publication.volume11pt
dc.date.embargo2021-03-30*
uc.date.periodoEmbargo0pt
item.fulltextCom Texto completo-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairetypearticle-
item.cerifentitytypePublications-
crisitem.project.grantnoIBEB-
crisitem.project.grantnoResearch Institute for Medicines - iMed.ULisboa-
crisitem.project.grantnoResearch Institute for Medicines - iMed-
Appears in Collections:FFUC- Artigos em Revistas Internacionais
I&D ICBR - Artigos em Revistas Internacionais
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