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Title: Regenerative Strategies in Cleft Palate: An Umbrella Review
Authors: Francisco, Inês 
Paula, Anabela Baptista 
Oliveiros, Bárbara 
Fernandes, Maria Helena
Carrilho, Eunice 
Marto, Carlos Miguel 
Vale, Francisco 
Keywords: autogenous graft; biomaterials; cleft palate; bone grafting; regenerative
Issue Date: 3-Jun-2021
Publisher: MDPI AG
Serial title, monograph or event: Bioengineering
Volume: 8
Issue: 6
Abstract: (1) Background: Alveolar bone defects or decreased alveolar bone height and width may have different causes, such as cleft palate. Regenerative procedures in oro-dental defects are challenging due to anatomical factors and the distinct cell populations involved. The iliac crest bone graft remains the gold-standard for cleft palate closure. However, tissue regeneration approaches have been employed and their outcome reviewed, but no conclusions have been made about which one is the gold-standard. (2) Methods: this umbrella review aims to critically appraise the effectiveness of the current approaches in bone defects regeneration in non-syndromic patients with cleft palate. A search was performed in PubMed, Cochrane Library, Scopus, Web of Science and EMBASE databases. (3) Results: Systematic reviews of randomized and non-randomized controlled trials with or without meta-analysis were included. Nine articles were included in the qualitative analysis and five in the quantitative one. The included studies quality was evaluated with AMSTAR2. (4) Conclusions: The use of new regenerative strategies, such as bone morphogenic protein 2, appears to provide similar results regarding bone volume, filling, and height to the standard technique with the iliac crest bone graft.
ISSN: 2306-5354
DOI: 10.3390/bioengineering8060076
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
I&D ICBR - Artigos em Revistas Internacionais
I&D CIBB - Artigos em Revistas Internacionais

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