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Title: Synthesis, Characterization, and Relaxivity of Two Linear Gd(DTPA)−Polymer Conjugates
Authors: Duarte, M. G. 
Gil, M. H. 
Peters, J. A. 
Colet, J. M. 
Elst, L. Vander 
Muller, R. N. 
Geraldes, C. F. G. C. 
Issue Date: 21-Mar-2001
Publisher: American Chemical Society
Citation: Bioconjugate Chemistry. 12:2 (2001) 170-177
Abstract: Two linear polyamide conjugates of Gd(DTPA)2- were synthesized and characterized by high-resolution nuclear magnetic resonance (NMR) spectroscopy and size exclusion chromatography (SEC). DTPA was copolymerized with two different diamines, 1,6-hexanediamine and trans-1,4-cyclohexanediamine, yielding the polymers DTPA-HMD and DTPA-CHD, with low polydispersity. Their molecular flexibility in solution was studied using 13C spin−lattice relaxation time measurements, indicating that the cyclohexanediamine linking moiety of the DTPA-HMD polymer is more rigid than that of DTPA-CHD. The influence of the flexibility of the linking functionalities on the relaxivity of the Gd3+-DTPA-polymer conjugates was studied by water nuclear magnetic relaxation dispersion (NMRD). The relaxivity of the Gd(DTPA-CHD) polymer was only slightly higher than that of the Gd(DTPA-HMD) polymer, and only two times higher than the usual values for small Gd-DTPA-like chelates. The low relaxivities obtained for both polymers, much lower than expected from the polymer apparent molecular weights, result from their substantial residual flexibility, and also from a too long, nonoptimal, value of the inner-sphere water exchange rate. These polymeric compounds are also cleared very quickly from the blood of rats, indicating that they are of limited value as blood pool contrast agents for MRA.
ISSN: 1043-1802
DOI: 10.1021/bc000065r
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
FCTUC Eng.Química - Artigos em Revistas Internacionais

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