Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/103192
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Vojtek, Martin | - |
dc.contributor.author | Gonçalves-Monteiro, Salomé | - |
dc.contributor.author | Šeminská, Patrícia | - |
dc.contributor.author | Valová, Katarína | - |
dc.contributor.author | Bellón, Loreto | - |
dc.contributor.author | Dias-Pereira, Patrícia | - |
dc.contributor.author | Marques, Franklim | - |
dc.contributor.author | Marques, Maria P. M. | - |
dc.contributor.author | Carvalho, Ana L. M. Batista de | - |
dc.contributor.author | Mota-Filipe, Helder | - |
dc.contributor.author | Ferreira, Isabel M P L V O | - |
dc.contributor.author | Diniz, Carmen | - |
dc.date.accessioned | 2022-10-20T10:37:52Z | - |
dc.date.available | 2022-10-20T10:37:52Z | - |
dc.date.issued | 2022-01-19 | - |
dc.identifier.issn | 2227-9059 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/103192 | - |
dc.description.abstract | Pd2Spm is a dinuclear palladium(II)-spermine chelate with promising anticancer properties against triple-negative breast cancer (TNBC), a breast carcinoma subset with poor prognosis and limited treatment options. The present study evaluated the in vitro and in vivo anticancer effects of Pd2Spm compared to the reference metal-based drug cisplatin. Triple-negative breast cancer MDA-MB-231 cells, non-cancerous MCF-12A breast cells and chorioallantoic membrane (CAM) assay were used for antiproliferative, antimigratory and antiangiogenic studies. For an in vivo efficacy study, female CBA nude mice with subcutaneously implanted MDA-MB-231 breast tumors were treated with Pd2Spm (5 mg/kg/day) or cisplatin (2 mg/kg/day) administered intraperitoneally during 5 consecutive days. Promising selective antiproliferative activity of Pd2Spm was observed in MDA-MB-231 cells (IC50 values of 7.3-8.3 µM), with at least 10-fold lower activity in MCF-12A cells (IC50 values of 89.5-228.9 µM). Pd2Spm inhibited the migration of MDA-MB-231 cells, suppressed angiogenesis in CAM and decreased VEGF secretion from MDA-MB-231 cells with similar potency as cisplatin. Pd2Spm-treated mice showed a significant reduction in tumor growth progression, and tumors evidenced a reduction in the Ki-67 proliferation index and number of mitotic figures, as well as increased DNA damage, similar to cisplatin-treated animals. Encouragingly, systemic toxicity (hematotoxicity and weight loss) observed in cisplatin-treated animals was not observed in Pd2Spm-treated mice. The present study reports, for the first time, promising cancer selectivity, in vivo antitumor activity towards TNBC and a low systemic toxicity of Pd2Spm. Thus, this agent may be viewed as a promising Pd(II) drug candidate for the treatment of this type of low-prognosis neoplasia. | pt |
dc.language.iso | eng | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Pd(II)-based drugs | pt |
dc.subject | cisplatin | pt |
dc.subject | metal complexes | pt |
dc.subject | triple-negative breast cancer | pt |
dc.subject | in vivo | pt |
dc.subject | xenografts | pt |
dc.title | Pd2Spermine Complex Shows Cancer Selectivity and Efficacy to Inhibit Growth of Triple-Negative Breast Tumors in Mice | pt |
dc.type | article | - |
degois.publication.firstPage | 210 | pt |
degois.publication.issue | 2 | pt |
degois.publication.title | Biomedicines | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/biomedicines10020210 | pt |
degois.publication.volume | 10 | pt |
dc.date.embargo | 2022-01-19 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | QFM-UC – Molecular Physical-Chemistry R&D Unit | - |
crisitem.author.researchunit | QFM-UC – Molecular Physical-Chemistry R&D Unit | - |
crisitem.author.orcid | 0000-0002-8391-0055 | - |
crisitem.author.orcid | 0000-0003-1280-3321 | - |
Appears in Collections: | FCTUC Eng.Química - Artigos em Revistas Internacionais FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Pdsub2subSpermine-Complex-Shows-Cancer-Selectivity-and-Efficacy-to-Inhibit-Growth-of-TripleNegative-Breast-Tumors-in-MiceBiomedicines.pdf | 5.01 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
6
checked on Oct 7, 2024
WEB OF SCIENCETM
Citations
6
checked on Oct 2, 2024
Page view(s)
124
checked on Oct 8, 2024
Download(s)
105
checked on Oct 8, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License