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https://hdl.handle.net/10316/10278
Title: | N-Vinyl- and C-Vinylpyrroles from Azafulvenium Methides. Flash Vacuum Pyrolysis Route to 5-Oxo-5H-pyrrolizines and 1-Azabenzo[f]azulenes | Authors: | Melo, Teresa M. V. D. Pinho e Soares, Maria I. L. Gonsalves, António M. d'A. Rocha Paixão, José A. Beja, Ana Matos Silva, Manuela Ramos |
Issue Date: | 19-Aug-2005 | Publisher: | American Chemical Society | Citation: | The Journal of Organic Chemistry. 70:17 (2005) 6629-6638 | Abstract: | 1-Azafulvenium methides, generated from pyrrolo[1,2-c]thiazole-2,2-dioxides' thermal extrusion of sulfur dioxide, led to the synthesis of functionalized pyrroles. The intramolecular trapping of these transient 8π 1,7-dipoles in pericyclic reactions, namely sigmatropic [1,8]H shifts and 1,7-electrocyclization, allowed the synthesis of N-vinylpyrroles and C-vinylpyrroles which, under flash vacuum pyrolysis conditions, are converted into 5-oxo-5H-pyrrolizines or 4-oxo-1,4-dihydro-1-aza-benzo[f]azulenes, respectively. These heterocycles can also be obtained directly from FVP of pyrrolo[1,2-c]thiazole 2,2-dioxides. The synthesis and X-ray structure of a new 6-oxocyclopenta[b]pyrrole derivative is also reported. | URI: | https://hdl.handle.net/10316/10278 | ISSN: | 0022-3263 | DOI: | 10.1021/jo050480i | Rights: | openAccess |
Appears in Collections: | FCTUC Física - Artigos em Revistas Internacionais FCTUC Química - Artigos em Revistas Internacionais |
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