Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/10264
Title: Solubility of Diflunisal in Supercritical Carbon Dioxide
Authors: Coimbra, Patrícia 
Fernandes, Daniel 
Gil, Maria H. 
Sousa, Hermínio C. de 
Issue Date: 14-Aug-2008
Publisher: American Chemical Society
Citation: Journal of Chemical & Engineering Data. 53:8 (2008) 1990-1995
Abstract: The solubility of diflunisal, a nonsteroidal anti-inflammatory drug (NSAID), in supercritical carbon dioxide (scCO2) was measured at (308.2, 318.2, and 328.2) K and in the pressure range from (9.0 up to 25.0) MPa. Results were obtained using a static analytical method. Experimental solubility was found to be between 0.54·10−6 and 8.07·10−6 (in terms of diflunisal mole fraction). Experimental data were satisfactorily correlated with an equation-of-state (EOS) model: the Peng−Robinson cubic equation of state (PR−EOS) together with the conventional van der Waals mixing and combining rules. Solid properties were estimated by different methods available in the literature. The solubilities of several NSAIDs in SCFs, namely in scCO2, were obtained from the literature and plotted and represented as a function of the corresponding sublimation pressures and fusion temperatures.
URI: http://hdl.handle.net/10316/10264
ISSN: 0021-9568
DOI: 10.1021/je800384h
Rights: openAccess
Appears in Collections:FCTUC Eng.Química - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
Solubility of Diflunisal in Supercritical Carbon Dioxide.pdf85.29 kBAdobe PDFView/Open
Show full item record

SCOPUSTM   
Citations

21
checked on Feb 18, 2020

WEB OF SCIENCETM
Citations

21
checked on Sep 14, 2020

Page view(s)

144
checked on Sep 23, 2020

Download(s)

146
checked on Sep 23, 2020

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.