Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/101618
Title: A mechanism for red coloration in vertebrates
Authors: Toomey, Matthew B.
Marques, Cristiana I.
Araújo, Pedro M. 
Huang, Delai
Zhong, Siqiong
Liu, Yu
Schreiner, Gretchen D.
Myers, Connie A.
Pereira, Paulo
Afonso, Sandra 
Andrade, Pedro
Gazda, Małgorzata A.
Lopes, Ricardo J. 
Viegas, Ivan 
Koch, Rebecca E.
Haynes, Maureen E.
Smith, Dustin J.
Ogawa, Yohey
Murphy, Daniel
Kopec, Rachel E.
Parichy, David M.
Carneiro, Miguel . 
Corbo, Joseph C.
Issue Date: 25-Aug-2022
Publisher: Elsevier; Cell Press
Project: info:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST/00152/2018/PT 
info:eu-repo/grantAgreement/EC/H2020/101000504/EU/The Genetic, Cellular, and Photonic Mechanisms of Avian Structural Colouration 
2020.01405.CEECIND/CP1601/CT0011 
2020.01494.CEECIND 
PD/BD/ 114042/2015 
PD/BD/28492/2017 
info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH/BD/147030/2019/PT/The Colour of Cooperation: linking colour polymorphism to mutualistic behaviour in the Caribbean sharknose cleaning goby Elacatinus evelynae 
Serial title, monograph or event: Current Biology
Abstract: Red coloration is a salient feature of the natural world. Many vertebrates produce red color by converting dietary yellow carotenoids into red ketocarotenoids via an unknown mechanism. Here, we show that two enzymes, cytochrome P450 2J19 (CYP2J19) and 3-hydroxybutyrate dehydrogenase 1-like (BDH1L), are sufficient to catalyze this conversion. In birds, both enzymes are expressed at the sites of ketocarotenoid biosynthesis (feather follicles and red cone photoreceptors), and genetic evidence implicates these enzymes in yellow/red color variation in feathers. In fish, the homologs of CYP2J19 and BDH1L are required for ketocarotenoid production, and we show that these enzymes are sufficient to produce ketocarotenoids in cell culture and when ectopically expressed in fish skin. Finally, we demonstrate that the red-cone-enriched tetratricopeptide repeat protein 39B (TTC39B) enhances ketocarotenoid production when co-expressed with CYP2J19 and BDH1L. The discovery of this mechanism of ketocarotenoid biosynthesis has major implications for understanding the evolution of color diversity in vertebrates.
URI: https://hdl.handle.net/10316/101618
ISSN: 09609822
DOI: 10.1016/j.cub.2022.08.013
Rights: embargoedAccess
Appears in Collections:I&D CFE - Artigos em Revistas Internacionais
I&D MARE - Artigos em Revistas Internacionais

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