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https://hdl.handle.net/10316/101617
Title: | Design and synthesis of novel indole-quinoxaline hybrids to target phosphodiesterase 4 (PDE4) | Authors: | Luther, Bethala Jawahar Rani, Chekuri Sharmila Suresh, Namburi Basaveswara Rao, Mandava V. Kapavarapu, Ravikumar Suresh, Chakali Vijaya Babu, P. Pal, Manojit |
Keywords: | Indole; Quinoxaline; Pd/C; PDE4 | Issue Date: | 2019 | Serial title, monograph or event: | Arabian Journal of Chemistry | Volume: | 12 | Issue: | 8 | Abstract: | A series of novel hybrid molecules were designed rationally by connecting an indole moiety with a quinoxaline ring through a linker as potential inhibitors of PDE4. Their design was validated initially in silico by performing docking studies using a representative molecule. Subsequent synthesis of a focused library of related hybrid molecules was accomplished using Pd/CACu mediated coupling-cyclization as a key step. Some of the synthesized compounds showed PDE4 inhibition in vitro and one of them appeared to be promising. | URI: | https://hdl.handle.net/10316/101617 | ISSN: | 18785352 | DOI: | 10.1016/j.arabjc.2015.08.009 | Rights: | openAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
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1-s2.0-S187853521500249X-main.pdf | 1.08 MB | Adobe PDF | View/Open |
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