Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/101263
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Moreira-de-Sá, Ana | - |
dc.contributor.author | Gonçalves, Francisco Q. | - |
dc.contributor.author | Lopes, João P. | - |
dc.contributor.author | Silva, Henrique B. | - |
dc.contributor.author | Tomé, Ângelo R. | - |
dc.contributor.author | Cunha, Rodrigo A. | - |
dc.contributor.author | Canas, Paula | - |
dc.date.accessioned | 2022-08-18T10:55:50Z | - |
dc.date.available | 2022-08-18T10:55:50Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 09699961 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/101263 | - |
dc.description.abstract | Angelman syndrome (AS) is a neurodevelopmental disorder caused by loss of function of the maternally inherited Ube3a neuronal protein, whose main features comprise severe intellectual disabilities and motor impairments. Previous studies with the Ube3am-/p+ mouse model of AS revealed deficits in synaptic plasticity and memory. Since adenosine A2A receptors (A2AR) are powerful modulators of aberrant synaptic plasticity and A2AR blockade prevents memory dysfunction in various brain diseases, we tested if A2AR could control deficits of memory and hippocampal synaptic plasticity in AS. We observed that Ube3am-/p+ mice were unable to resort to hippocampal-dependent search strategies when tested for learning and memory in the Morris water maze; this was associated with a decreased magnitude of long-term depression (LTD) in CA1 hippocampal circuits. There was an increased density of A2AR in the hippocampus of Ube3am-/p+ mice and their chronic treatment with the selective A2AR antagonist SCH58261 (0.1 mg/kg/day, ip) restored both hippocampal-dependent learning strategies, as well as LTD deficits. Altogether, this study provides the first evidence of a role of A2AR as a new prospective therapeutic target to manage learning deficits in AS. | pt |
dc.description.sponsorship | This research work was supported by Fundação Amélia de Mello | pt |
dc.language.iso | eng | pt |
dc.relation | CENTRO-01-0145-FEDER-000008:BrainHealth 2020 | pt |
dc.relation | CENTRO-01-0246-FEDER-000010 | pt |
dc.relation | POCI-01-0145-FEDER-031274 | pt |
dc.relation | info:eu-repo/grantAgreement/UIDB/04539/2020 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt |
dc.subject | Adenosine A(2A) receptor | pt |
dc.subject | Angelman syndrome | pt |
dc.subject | Hippocampus | pt |
dc.subject | Mouse model | pt |
dc.subject | Synaptic plasticity | pt |
dc.subject | Ube3a | pt |
dc.subject.mesh | Adenosine | pt |
dc.subject.mesh | Angelman Syndrome | pt |
dc.subject.mesh | Animals | pt |
dc.subject.mesh | Disease Models, Animal | pt |
dc.subject.mesh | Hippocampus | pt |
dc.subject.mesh | Learning | pt |
dc.subject.mesh | Memory | pt |
dc.subject.mesh | Mice | pt |
dc.subject.mesh | Mice, Inbred C57BL | pt |
dc.subject.mesh | Neuronal Plasticity | pt |
dc.title | Adenosine A2A receptors format long-term depression and memory strategies in a mouse model of Angelman syndrome | pt |
dc.type | article | - |
degois.publication.firstPage | 105137 | pt |
degois.publication.title | Neurobiology of Disease | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1016/j.nbd.2020.105137 | pt |
degois.publication.volume | 146 | pt |
dc.date.embargo | 2020-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology - CIBB | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-5468-2647 | - |
crisitem.author.orcid | 0000-0001-8042-0221 | - |
crisitem.author.orcid | 0000-0002-5122-1802 | - |
crisitem.author.orcid | 0000-0002-7234-3411 | - |
crisitem.author.orcid | 0000-0001-8671-989X | - |
crisitem.author.orcid | 0000-0003-2550-6422 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
1-s2.0-S0969996120304125-main.pdf | 2.37 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
12
checked on Jul 1, 2024
WEB OF SCIENCETM
Citations
12
checked on Jul 2, 2024
Page view(s)
145
checked on Oct 16, 2024
Download(s)
57
checked on Oct 16, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License