Carvalho, Luís A. E. Batista de

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Credit Name
Carvalho, Luís A. E. Batista de
 
Name
Carvalho, Luís Batista de
 
Variants
Carvalho, Luís A. E.
Carvalho, Luís A. E. Batista de
 
 
 
Ciência ID
 
Researcher ID
 
Status
UC Researcher
Biography
Luís Alberto E. Batista de Carvalho (January 1961, Coimbra, Portugal) received his BSc (Hons) from the Department of Chemistry, Faculty of Science and Technology, University of Coimbra (1984) and his PhD in Chemistry, specialty Physical-Chemistry, from Faculty of Sciences, University of Lisbon (1993). He is currently associate professor at the Department of Chemistry, University of Coimbra and head of the “Molecular Physical-Chemistry” R&D Unit. Throughout his career he has developed several scientific research projects, in collaboration with national and international groups, in the areas of Medicinal Chemistry, Pharmaceutical Technology and Chemistry/Forensic Anthropology with special emphasis on the application of spectroscopic techniques: i) to the structural analysis of compounds of biological interest; ii) the development of new anti-cancer agents containing Pt and Pd (in particular, the determination of new therapeutic targets in order to optimize efficacy and minimize side effects and acquired resistance); iii) the study of drug/cell interactions in model systems (cancer cell lines) with a view to understanding the molecular mechanisms underlying cytotoxic activity; and iv) the analysis of changes induced by burning processes in human skeletons. He has preferably used vibrational spectroscopy, optical and with neutrons, including microRaman spectroscopy and FTIR with synchrotron radiation. Recently, and in conjunction with the aforementioned themes that he continues to develop, he started a research project that aims to apply vibrational spectroscopy techniques to the early diagnosis of cancer and rigorous determination of surgical margins (in the removal of malignant tumours). This subject involves not only methodological development but also the construction of a new Raman spectroscopy apparatus that increases the speed of diagnosis with a view to translate this technology to the clinics in the near future.
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Publications
(All)

Refined By:
Date Issued:  [2010 TO 2020]
Author:  Marques, M. Paula M.

Results 1-43 of 43 (Search time: 0.031 seconds).

Issue DateTitleAuthor(s)TypeAccess
1Sep-2013A conformational study of hydroxylated isoflavones by vibrational spectroscopy coupled with DFT calculationsMachado, N. F. L. ; Carvalho, L. A. E. Batista de ; Otero, J. C. ; Marques, M. P. M. articleopenAccess
21-Jan-2017An EXAFS Approach to the Study of Polyoxometalate–Protein Interactions: The Case of Decavanadate–ActinMarques, M. Paula M. ; Gianolio, Diego ; Ramos, Susana ; Carvalho, Luís A. E. Batista de ; Aureliano, Manuel articleembargoedAccess
32014An inelastic neutron scattering study of dietary phenolic acidsMarques, M. P. M. ; Carvalho, Luís A. E. Batista de ; Valero, Rosendo ; Machado, Nelson F. L. ; Parker, Stewart F. articleopenAccess
42017Ancient burned Human Remains Probed by Neutron and Optical Vibrational SpectroscopyFesta, G. ; Rickards, O. ; Martinez-Labarga, C. ; Martini, F. ; Marques, M. P. M. ; Carvalho, L. A. E. Batista de ; Gonçalves, D. ; Parker, S. F. ; Andreani, C. conferenceObjectopenAccess
51-Jan-2017Anomalous surface-enhanced Raman scattering of aromatic aldehydes and carboxylic acidsMachado, N. F. L. ; Marques, M. P. M. ; Carvalho, L. A. E. Batista de ; Castro, J. L. ; Otero, J. C. articleembargoedAccess
62013Applying vibrational spectroscopy to the study of nucleobases – adenine as a case-studyLopes, Rui P. ; Valero, Rosendo ; Tomkinson, John ; Marques, M. P. M. ; Carvalho, Luís A. E. Batista de articleopenAccess
72011Biologic Activity of a Dinuclear Pd(II)-Spermine Complex Toward Human Breast CancerFiuza, Sónia M. ; Holy, Jon ; Carvalho, Luís A. E. Batista de ; Marques, Maria P. M. articleopenAccess
82018Biomaterials from human bone – probing organic fraction removal by chemical and enzymatic methodsMamede, A. P. ; Vassalo, A. R. ; Cunha, E. ; Gonçalves, D. ; Parker, S. F. ; Carvalho, L. A. E. Batista de ; Marques, M. P. M. articleopenAccess
92017Burned bones tell their own stories: A review of methodological approaches to assess heat-induced diagenesisMamede, Adriana P. ; Gonçalves, David ; Marques, Maria Paula Matos ; Carvalho, Luís A. E. Batista de articleopenAccess
101-Jan-2016Characterization of decavanadate and decaniobate solutions by Raman spectroscopyAureliano, Manuel ; Ohlin, C. André ; Vieira, Michele O. ; Marques, M. Paula M. ; Casey, William H. ; Carvalho, Luís A. E. Batista de articleopenAccess
1111-Jan-2016Chemotherapeutic response to cisplatin-like drugs in human breast cancer cells probed by vibrational microspectroscopyCarvalho, A. L. M. Batista de ; Pilling, M. ; Gardner, P. ; Doherty, J. ; Cinque, G. ; Wehbe, K. ; Kelley, C. ; Carvalho, L. A. E. Batista de ; Marques, M. P. M. articleopenAccess
121-Jan-2015Comment on “Assessment of new DFT methods for predicting vibrational spectra and structure of cisplatin: Which density functional should we choose for studying platinum(II) complexes?” [Spectrochim. Acta A125 (2014) 431–439]Marques, Maria Paula M. ; Carvalho, Luís A. E. Batista de ; Parker, Stewart F. articleopenAccess
132010Conformational and vibrational study of cis-diamminedichloropalladium(ii)Fiuza, Sónia M. ; Amado, Ana M. ; Santos, Hélio F. Dos ; Marques, Maria P. M. ; Carvalho, Luis A. E. Batista de articleopenAccess
142012Conformational behaviour of antioxidant chromones. A vibrational spectroscopy studyMachado, N. F. L. ; Valero, R. ; Domingos, H. S. ; Tomkinson, J. ; Carvalho, L. A. E. Batista de ; Otero, J. C. ; Marques, M. P. M. articleopenAccess
151-Jan-2015Conformational insights and vibrational study of a promising anticancer agent: the role of the ligand in Pd(ii)–amine complexesFiuza, Sónia M. ; Amado, Ana M. ; Parker, Stewart F. ; Marques, Maria Paula M. ; Carvalho, Luís A. E. Batista de articleopenAccess
161-Jan-2016Conformational study and reassessment of the vibrational assignments for NorspermidineSilva, T. M. ; Fiuza, S. M. ; Marques, M. P. M. ; Carvalho, L. A. E. Batista de ; Amado, A. M. articleopenAccess
171-Jan-2013A conformational study of hydroxyflavones by vibrational spectroscopy coupled to DFT calculationsMachado, N. F. L. ; Carvalho, L. A. E. Batista de ; Otero, J. C. ; Marques, M. P. M. articleopenAccess
18Jun-2018Crystal clear: Vibrational spectroscopy reveals intrabone, intraskeleton, and interskeleton variation in human bonesGonçalves, D. ; Vassalo, A. R. ; Mamede, A. ; Makhoul, C. ; Piga, G. ; Cunha, E. ; Marques, M. P. M. ; Carvalho, L. A. E. Batista de articlerestrictedAccess
192012Decavanadate, decaniobate, tungstate and molybdate interactions with sarcoplasmic reticulum Ca2+-ATPase: quercetin prevents cysteine oxidation by vanadate but does not reverse ATPase inhibitionFraqueza, Gil ; Carvalho, Luís A. E. Batista de ; Marques, M. Paula M. ; Maia, Luisa ; Ohlin, C. André ; Casey, William H. ; Aureliano, Manuel articleopenAccess
202018Eating the bone! An enzymatic protocol aiming at bone’s organic matrix removalMamede, A. P. ; Vassalo, A. R. ; Gonçalves, David ; Parker, S. F. ; Carvalho, L. A. E. Batista de ; Marques, M. P. M. conferenceObjectopenAccess
211-Jan-2016Faraday Discussions – "Advanced Vibrational Spectroscopy for Biomedical Applications”Carvalho, A. L. M. Batista de ; Pilling, M. ; Gardner, P. ; Doherty, J. ; Cinque, G. ; Wehbe, K. ; Kelley, C. ; Carvalho, L. A. E. Batista de ; Marques, M. P. M. bookPartopenAccess
222012Functional and Structural Interactions of Nb, V, Mo and W Oxometalates with the Sarcoplasmic Reticulum Ca2+-ATPase Reveal New Insights Into Inhibition Processes: a Combination of NMR, Raman, AA and EPR Spectroscopies with Kinetic StudiesFraqueza, G. ; Carvalho, L. A. E. Batista de ; Marques, M. P. M. ; Ohlin, C. A. ; Casey, W. H. ; Aureliano, M. articleopenAccess
232012Guanine: A Combined Study Using Vibrational Spectroscopy and Theoretical MethodsLopes, R. Pedro ; Marques, M. Paula M. ; Valero, Rosendo ; Tomkinson, John ; Carvalho, Luís A. E. Batista de articleopenAccess
242018Heat-induced Bone Diagenesis Probed by Vibrational SpectroscopyMarques, M. P. M. ; Mamede, A. P. ; Vassalo, A. R. ; Makhoul, C. ; Cunha, E. ; Gonçalves, D. ; Parker, S. F. ; Carvalho, L. A. E. Batista de articleopenAccess
252011Inelastic Neutron Scattering Study of PtII Complexes Displaying Anticancer PropertiesCarvalho, Luís A. E. Batista de ; Marques, M. Paula M. ; Martin, Christine ; Parker, Stewart F. ; Tomkinson, John articleopenAccess
2625-Jan-2017Intracellular water - an overlooked drug target? Cisplatin impact in cancer cells probed by neutronsMarques, M. P. M. ; Carvalho, A. L. M. Batista de ; Sakai, V Garcia ; Hatter, L ; Carvalho, L. A. E. Batista de articleembargoedAccess
272018Le potentiel des groupes hydroxyles de la bioapatite pour discriminer des os brulés humains par spectroscopie vibrationelleGonçalves, David ; Mamede, Adriana P. ; Vassalo, Ana Rita ; Piga, Giampaolo ; Cunha, Eugénia ; Parker, Stewart F. ; Marques, Maria Paula Matos ; Carvalho, Luís A. E. Batista de conferenceObjectopenAccess
281-Jan-2013Main Symposia And WorkshopsFiuza, S. M. ; Amado, A.M. ; Marques, M. P. M. ; Carvalho, L. A. E. Batista de articleopenAccess
2921-Feb-2015A molecular view of cisplatin's mode of action: interplay with DNA bases and acquired resistanceMarques, M. P. M. ; Gianolio, Diego ; Cibin, Giannantonio ; Tomkinson, John ; Parker, Stewart F. ; Valero, Rosendo ; Pedro Lopes, R ; Carvalho, Luís A. E. Batista de articleopenAccess
302013New sustained release of Zidovudine Matrix tablets − cytotoxicity toward Caco-2 cellsSantos, Jucimary V. ; Pina, Maria Eugénia T. ; Marques, M. P. M. ; Carvalho, Luís A. E. Batista de articleopenAccess
311-Jan-2015On the correction of calculated vibrational frequencies for the effects of the counterions — α,ω-diamine dihydrochloridesFiuza, S. M. ; Silva, T. M. ; Marques, M. P. M. ; Carvalho, L. A. E. Batista de ; Amado, A. M. articleopenAccess
3213-Jul-2016Osteometrics in burned human skeletal remains by neutron and optical vibrational spectroscopyMarques, M. P. M. ; Gonçalves, D. ; Amarante, A. I. C. ; Makhoul, C. I. ; Parker, S. F. ; Carvalho, L. A. E. Batista de articleopenAccess
332013Polymorphism in Cisplatin Anticancer DrugMarques, M. Paula M. ; Valero, Rosendo ; Parker, Stewart F. ; Tomkinson, John ; Carvalho, Luís A. E. Batista de articleopenAccess
342-Oct-2018Potential of Bioapatite Hydroxyls for Research on Archeological Burned BoneMamede, Adriana P. ; Vassalo, Ana R. ; Piga, Giampaolo ; Cunha, Eugénia ; Parker, Stewart F. ; Marques, M. Paula M. ; Carvalho, Luís A. E. Batista de ; Gonçalves, David articlerestrictedAccess
352012Pt(II) Complexes with Linear Diamines—Part I: Vibrational Study of Pt-DiaminopropaneCarvalho, Ana L. M. Batista de ; Fiuza, Sónia M. ; Tomkinson, John ; Carvalho, Luís A. E. Batista de ; Marques, M. Paula M. articleopenAccess
361-Jan-2016Raman spectroscopic evidence for the inclusion of decanoate ion in trimethyl-β-cyclodextrinSeiça, Ana Filipa ; Carvalho, Luís A. E. Batista de ; Marques, M. Paula M. ; Dias, José J. C. Teixeira articleopenAccess
371-Jan-2013Spectroscopy of Biological Molecules”, Série Advances in Biomedical SpectroscopyLopes, R.P. ; Marques, M. P. M. ; Valero, R. ; Tomkinson, J. ; Carvalho, L. A. E. Batista de bookPartopenAccess
381-Jan-2013“Spectroscopy of Biological Molecules”, Série Advances in Biomedical Spectroscopy, vol. 7Carvalho, A. L. M. Batista de ; Fiuza, S. M. ; Tomkinson, J. ; Carvalho, L. A. E. Batista de ; Marques, M. P. M. bookPartopenAccess
392018Targeting the OH’s within Bone´s Bioapatite by Neutron and Optical Vibrational SpectroscopyMamede, A. P. ; Vassalo, A. R. ; Piga, G. ; Cunha, E. ; Parker, S. F. ; Marques, M. P. M. ; Carvalho, L. A. E. Batista de ; Gonçalves, D. conferenceObjectopenAccess
402012The autooxidation process in linoleic acid screened by Raman spectroscopyMachado, N. F. L. ; Carvalho, L. A. E. Batista de ; Otero, J. C. ; Marques, M. P. M. articleopenAccess
412018Unravelling the mystery: FTIR-ATR and inelastic neutron scattering (INS) spectroscopies applied to the analysis of burned human skeletal remainsVassalo, A. R. ; Mamede, P. ; Cunha, E. ; Parker, S. F. ; Marques, Maria Paula Matos ; Gonçalves, D. ; Carvalho, L. A. E. Batista de conferenceObjectopenAccess
421-Jan-2017Vibrational and conformational studies of 1,3-diaminopropane and its N-deuterated and N-ionised derivativesMendes, Sofia R. O. ; Amado, Ana M. ; Tomkinson, John ; Marques, M. Paula M. ; Carvalho, Luís A. E. Batista de articleembargoedAccess
432018Widening the frontiers in Forensic Identification: probing burned human bones with neutron techniquesMamede, A. P. ; Vassalo, A. R. ; Makhoul, C. ; Gonçalves, D. ; Parker, S. F. ; Kockelman, W ; Marques, Maria Paula Matos ; Carvalho, Luís A. E. Batista de articleopenAccess