This work was financed by the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme under project CENTRO-01-0246-FEDER-000010 (Multidisciplinary Institute of Ageing in Coimbra) through the COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation and Portuguese national funds via FCT – Fundação para a Ciência e a Tecnologia, under project[s] PTDC/ASP-HOR/29152/2017, POCI-01-0145-FEDER- 029152, UIDB/04033/2020, UIDB/04539/2020, UIDP/04539/2020 and LA/P/0058/2020. José Pedro Castelão-Baptista was supported by the project “Summer Course in Interdisciplinary Research, Development and Innovation in Cellular and Molecular Metabolism” (15-20/7/245), funded by the Portuguese Foundation for Science and Technology (FCT) and the Directorate General for Higher Education (DGES).