This research was financed by Portuguese Foundation for Science and Technology (FCT) through national funds and the co-funding by FEDER- Fundo Europeu de Desenvolvimento Regional and COMPETEPrograma Operacional Factores de Competitividade, under the projects FCT PTDC/AGR-CFL/098916/2008 and FCT PTDC/NEU-NMC/0205/2012, within the PT2020 Partnership Agreement and COMPETE 2020 under the projects UID/BIA/04004/2013 and UID/NEU/04539/2013, the National Mass Spectrometry Network (RNEM, REDE/1506/REM/2005) and Instituto do Ambiente, Tecnologia e Vida, FCTUC. Joana M.S. Cardoso (SFRH/BPD/73724/2010) and Sandra I. Anjo (SFRH/BD/81495/2011) are funded by post-doctoral/ doctoral fellowships financed by QREN-POPH-Typology 4.1-co-financed by MES national funding and The European Social Fund. Luís Fonseca (SFRH/BPD/101325/2014) is funded by post-doctoral fellowship financed by MEC national funding and by the European Social Fund through POCH (Programa Operacional Capital Humano).