financial support of the Portuguese Foundation for Science and Technology (FCT) through Strategic Projects UID/MAR/04292/2013 and UID/Multi/04046/2013 granted to MARE – Marine and Environmental Sciences Centre and BioISI - BioSystems and Integrative Sciences Institute, respectively, through Red2Discovery Project (PTDC/MAR-BIO/6149/2014), cofinanced by COMPETE (POCI-01-0145-FEDER-016791), and through Oncologia de Precisão: Terapias e Tecnologias Inovadoras project (POINT4PAC) (SAICTPAC/0019/2015 - LISBOA-01-0145-FEDER-016405). The authors also wish to acknowledge the Integrated Programme of SR&TD Smart Valorization of Endogenous Marine Biological Resources Under a Changing Climate (reference Centro-01-0145-FEDER- 000018), co-funded by Centro 2020 program, Portugal 2020, European Union, through the European Regional Development Fund. CA, SP, and JS are financial supported by a grant from FCT (SFRH/BD/97764/2013, SFRH/BD/96203/2013, and SFRH/BD/103255/2014, respectively).