PTDC/ASP-HOR/29152/2017

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Primary Data

Project title
PTDC/ASP-HOR/29152/2017
Code
VALORIZEBYPRODU Preclinical efficacy of sulforaphane or Brassica whole extract: a strategy to fight obesity and valorize Brassica byproducts
Start date
01-06-2018
Expected Completion
28-02-2022
 

Description

Abstract
According to WHO, in 2014, 11% of men and 15% of women were obese. In 2008, the direct costs associated to obesity in Portugal was estimated in 85,9 million euros. A healthy lifestyle is crucial to prevent overweight and obesity. So, the availability of supplements made of natural compounds to fight obesity is of great importance. Sulforaphane (SFN) is an isothiocyanate derived from glucoraphanin, a phytochemical present in Brassica vegetables (cabbages, broccoli, cauliflower). Preclinical studies showed that SFN have beneficial effects in the treatment of many diseases, including diabetes and cancer. In 2014, more than 5.3 million tonnes of Brassicas were produced in the European Union, with more than 183 thousand in Portugal, representing large amounts of byproducts with negative economic and environmental impacts.
 

Publications
(All)

Refined By:
Author:  Oliveira, Paulo J.

Results 1-6 of 6 (Search time: 0.008 seconds).

Issue DateTitleAuthor(s)TypeAccess
12021Afrostyrax lepidophyllus Mildbr. and Monodora myristica (Gaertn.) Dunal Extracts Decrease Doxorubicin Cytotoxicity on H9c2 CardiomyoblastsMoukette, Bruno ; Castelão-Baptista, José P. ; Ferreira, Luciana L. ; Silva, Ana M. ; Simões, Rui F. ; Cabral, Célia ; Pieme, Constant A.; Ngogang, Jeanne Y.; Sardão, Vilma A. ; Oliveira, Paulo J. articleopenAccess
212-Feb-2023Brassica oleracea Var italica by-Products Prevent Lipid Accumulation and Cell Death in a Liver Cell Model of Lipid ToxicityCastelão-Baptista, José P. ; Valente, Sara A. ; Canário, Sara ; Oppolzer, David; Barros, Ana; Venâncio, Carlos; Martins, Tânia ; Antunes, Luís; Sardão, Vilma A. ; Rosa, Eduardo; Oliveira, Paulo J. articleopenAccess
319-May-2021Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 CellsAmorim, Ricardo ; Simões, Inês C. M.; Veloso, Caroline ; Carvalho, Adriana ; Simões, Rui F. ; Pereira, Francisco B. ; Thiel, Theresa; Normann, Andrea; Morais, Catarina M. ; Jurado, Maria Amália da Silva ; Wieckowski, Mariusz R. ; Teixeira, José ; Oliveira, Paulo J. articleopenAccess
4Mar-2022Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex relationshipKarkucinska-Wieckowska, Agnieszka; Simoes, Ines C M; Kalinowski, Piotr; Lebiedzinska-Arciszewska, Magdalena; Zieniewicz, Krzysztof; Milkiewicz, Piotr; Górska-Ponikowska, Magdalena; Pinton, Paolo; Malik, Afshan N; Krawczyk, Marcin; Oliveira, Paulo J. ; Wieckowski, Mariusz R. articleopenAccess
514-Jan-2022The Role of Glucosinolates from Cruciferous Vegetables (Brassicaceae) in Gastrointestinal Cancers: From Prevention to TherapeuticsMelim, Catarina ; Lauro, Maria R.; Pires, Isabel M.; Oliveira, Paulo J. ; Cabral, Célia articleopenAccess
615-Oct-2020Western Diet Causes Obesity-Induced Nonalcoholic Fatty Liver Disease Development by Differentially Compromising the Autophagic ResponseSimoes, Ines C M; Karkucinska-Wieckowska, Agnieszka; Janikiewicz, Justyna; Szymanska, Sylwia; Pronicki, Maciej; Dobrzyn, Pawel; Dabrowski, Michal; Dobrzyn, Agnieszka; Oliveira, Paulo J. ; Zischka, Hans; Potes, Yaiza; Wieckowski, Mariusz R. articleopenAccess