Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/99941
Campo DC | Valor | Idioma |
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dc.contributor.author | Nogueira, Bernardo Albuquerque | - |
dc.contributor.author | Carvalho, Maria | - |
dc.contributor.author | Paixão, José António de Carvalho | - |
dc.contributor.author | Eusébio, M. Ermelinda | - |
dc.contributor.author | Lopes, Susana Margarida Martins | - |
dc.contributor.author | Melo, Teresa Margarida Vasconcelos Dias de Pinho e | - |
dc.contributor.author | Fausto, Rui | - |
dc.date.accessioned | 2022-04-26T09:04:27Z | - |
dc.date.available | 2022-04-26T09:04:27Z | - |
dc.date.issued | 2022-01-10 | - |
dc.identifier.issn | 1466-8033 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/99941 | - |
dc.description.abstract | A novel derivative of the prominent ROY compound, 5-acetyl-2-((2-nitrophenyl)amino)thiophene-3-carbonitrile (AcROY), was synthesized in a two-steps procedure by the nucleophilic aromatic substitution reaction between 1-fluoro-2-nitrobenzene and 2-aminothiophene-3-carbonitrile, followed by Friedel–Crafts acylation at position 5 of the thiophene ring. The conformational space of the compound (isolated molecule) was studied computationally, rendering 4 low-energy intramolecularly hydrogen-bonded conformers. The compound exhibits color polymorphism, with 3 different polymorphs identified. The crystal structures of two of the polymorphs were solved by single-crystal X-ray diffraction crystallography: polymorph 1 (burgundy) is monoclinic (P21/n; a = 5.3354(2) Å, b = 14.2344(4) Å, c = 17.1709(6) Å, = 96.567(2)º, Z = 4, Z’ = 1), and polymorph 2 (orange) is monoclinic (P21/c; a = 25.451(3) Å, b = 14.4966(14) Å, c = 7.1113(7) Å, = 95.795(6)º, Z = 8, Z’ = 2. It was not possible to determine the crystal structure of the third polymorph (3, orange-yellowish), but the obtained powder X-ray diffraction, infrared and Raman spectroscopy data clearly demonstrate the existence of this additional polymorphic form. Indexation of its powder diffraction pattern showed that it is a monoclinic variety with lattice parameters a = 11.383(3) Å, b = 13.6609(3) Å, c = 25.247(7) Å, β =101.75(1), thus exhibiting a more complex supramolecular structure compared to polymorphs 1 and 2. All polymorphs were characterized spectroscopically (by infrared and Raman spectroscopies) and by thermal analysis (by differential scanning calorimetry and polarized light thermomicroscopy). Interestingly, among the 4 predicted low energy conformers of the AcROY molecule, only the most stable form was found to be present in the crystals of the two structurally characterized polymorphs of the compound. The dominant intermolecular interactions in polymorphs 1 and 2 were investigated (also using Hirshfeld surface analysis) and were found to be significantly different. The observed polymorphism of AcROY is then an interesting case of packing-determined color polymorphism. | pt |
dc.language.iso | eng | pt |
dc.publisher | The Royal Society of Chemistry | pt |
dc.relation | UIDB/00313/2020 | pt |
dc.relation | UIDP/00313/2020 | pt |
dc.relation | UIDB/04564/2020 | pt |
dc.relation | UIDP/04564/2020 | pt |
dc.relation | SFRH/BD/129852/2017 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | 5-acetyl-2-((2-nitrophenyl)amino)thiophene-3-carbonitrile | pt |
dc.subject | ROY | pt |
dc.subject | color polymorphism | pt |
dc.subject | molecular structure | pt |
dc.subject | thermal analysis | pt |
dc.subject | infrared, Raman and NMR spectroscopies | pt |
dc.title | Portrayal of the Color Polymorphism in the 5-Acetyl-derivative of ROY | pt |
dc.type | article | - |
degois.publication.firstPage | 1459 | pt |
degois.publication.lastPage | 1474 | pt |
degois.publication.issue | 24 | pt |
degois.publication.title | CrystEngComm | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1039/d1ce01601f | pt |
degois.publication.volume | 24 | pt |
dc.date.embargo | 2022-01-10 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | Coimbra Chemistry Center | - |
crisitem.project.grantno | Coimbra Chemistry Center | - |
crisitem.project.grantno | Center for Physics of the University of Coimbra | - |
crisitem.project.grantno | Center for Physics of the University of Coimbra | - |
crisitem.author.researchunit | Faculty of Sciences and Technology | - |
crisitem.author.researchunit | CFisUC – Center for Physics of the University of Coimbra | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | University of Coimbra | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0002-1756-377X | - |
crisitem.author.orcid | 0000-0003-4634-7395 | - |
crisitem.author.orcid | 0000-0002-5515-7721 | - |
crisitem.author.orcid | 0000-0002-1580-5667 | - |
crisitem.author.orcid | 0000-0003-3256-4954 | - |
crisitem.author.orcid | 0000-0002-8264-6854 | - |
Aparece nas coleções: | I&D CQC - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Manuscript-AcROY-Rev2_Version-FINAL.pdf | 1.94 MB | Adobe PDF | Ver/Abrir |
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