Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/96865
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Abellán-Álvaro, María | - |
dc.contributor.author | Stork, Oliver | - |
dc.contributor.author | Agustín-Pavón, Carmen | - |
dc.contributor.author | Santos, Mónica | - |
dc.date.accessioned | 2021-12-30T16:18:49Z | - |
dc.date.available | 2021-12-30T16:18:49Z | - |
dc.date.issued | 2021-12-11 | - |
dc.identifier.issn | 1866-1947 | pt |
dc.identifier.issn | 1866-1955 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/96865 | - |
dc.description.abstract | Early-life stress can leave persistent epigenetic marks that may modulate vulnerability to psychiatric conditions later in life, including anxiety, depression and stress-related disorders. These are complex disorders with both environmental and genetic influences contributing to their etiology. Methyl-CpG Binding Protein 2 (MeCP2) has been attributed a key role in the control of neuronal activity-dependent gene expression and is a master regulator of experience-dependent epigenetic programming. Moreover, mutations in the MECP2 gene are the primary cause of Rett syndrome and, to a lesser extent, of a range of other major neurodevelopmental disorders. Here, we aim to study the interaction of MeCP2 with early-life stress in variables known to be affected by this environmental manipulation, namely anxiety-like behavior and activity of the underlying neural circuits. | pt |
dc.language.iso | eng | pt |
dc.publisher | BMC | pt |
dc.relation | PID2019-107322GB-C22 | pt |
dc.relation | CENTRO-01-0145-FEDER-000008 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Arginine-vasopressin | pt |
dc.subject | Corticotropin-releasing hormone | pt |
dc.subject | Maternal separation | pt |
dc.subject | Rett syndrome | pt |
dc.subject | c-FOS | pt |
dc.title | MeCP2 haplodeficiency and early-life stress interaction on anxiety-like behavior in adolescent female mice | pt |
dc.type | article | - |
degois.publication.firstPage | 59 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | Journal of Neurodevelopmental Disorders | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1186/s11689-021-09409-7 | pt |
degois.publication.volume | 13 | pt |
dc.date.embargo | 2021-12-11 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Journal of Neurodevelopmental Disorders _2021_ 13-59_Article_MeCP2HaplodeficiencyAndEarly-l.pdf | 4.31 MB | Adobe PDF | View/Open |
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