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Title: Luteolin Improves Perivascular Adipose Tissue Profile and Vascular Dysfunction in Goto-Kakizaki Rats
Authors: Queiroz, Marcelo
Leandro, Adriana 
Azul, Lara 
Figueirinha, Artur 
Seiça, Raquel 
Sena, Cristina M.
Keywords: Endothelial dysfunction; Inflammation
Issue Date: 20-Dec-2021
Publisher: MDPI
Project: POCI-01-0145-FEDER-007440 
Serial title, monograph or event: International Journal of Molecular Sciences
Volume: 22
Issue: 24
Abstract: We investigated the effects of luteolin on metabolism, vascular reactivity, and perivascular adipose tissue (PVAT) in nonobese type 2 diabetes mellitus animal model, Goto-Kakizaki (GK) rats. Methods: Wistar and GK rats were divided in two groups: (1) control groups treated with vehicle; (2) groups treated with luteolin (10 mg/kg/day, for 2 months). Several metabolic parameters such as adiposity index, lipid profile, fasting glucose levels, glucose and insulin tolerance tests were determined. Endothelial function and contraction studies were performed in aortas with (PVAT+) or without (PVAT−) periaortic adipose tissue. We also studied vascular oxidative stress, glycation and assessed CRP, CCL2, and nitrotyrosine levels in PVAT. Results: Endothelial function was impaired in diabetic GK rats (47% (GK − PVAT) and 65% (GK + PVAT) inhibition of maximal endothelial dependent relaxation) and significantly improved by luteolin treatment (29% (GK − PVAT) and 22% (GK + PVAT) inhibition of maximal endothelial dependent relaxation, p < 0.01). Vascular oxidative stress and advanced glycation end-products’ levels were increased in aortic rings (~2-fold, p < 0.05) of diabetic rats and significantly improved by luteolin treatment (to levels not significantly different from controls). Periaortic adipose tissue anti-contractile action was significantly rescued with luteolin administration (p < 0.001). In addition, luteolin treatment significantly recovered proinflammatory and pro-oxidant PVAT phenotype, and improved systemic and metabolic parameters in GK rats. Conclusions: Luteolin ameliorates endothelial dysfunction in type 2 diabetes and exhibits therapeutic potential for the treatment of vascular complications associated with type 2 diabetes. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
ISSN: 1422-0067
DOI: 10.3390/ijms222413671
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais

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