Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/95681
Title: A bioelectric model of carcinogenesis, including propagation of cell membrane depolarization and reversal therapies
Authors: Carvalho, João 
Issue Date: 30-Jun-2021
Publisher: Springer Nature
Project: UIDB/04564/2020 
UIDP/04564/2020 
Serial title, monograph or event: Scientific Reports
Volume: 11
Issue: 1
Abstract: As the main theory of carcinogenesis, the Somatic Mutation Theory, increasingly presents difficulties to explain some experimental observations, different theories are being proposed. A major alternative approach is the Tissue Organization Field Theory, which explains cancer origin as a tissue regulation disease instead of having a mainly cellular origin. This work fits in the latter hypothesis, proposing the bioelectric field, in particular the cell membrane polarization state, and ionic exchange through ion channels and gap junctions, as an important mechanism of cell communication and tissue organization and regulation. Taking into account recent experimental results and proposed bioelectric models, a computational model of cancer initiation was developed, including the propagation of a cell depolarization wave in the tissue under consideration. Cell depolarization leads to a change in its state, with the activation and deactivation of several regulation pathways, increasing cell proliferation and motility, changing its epigenetic state to a more stem cell-like behavior without the requirement of genomic mutation. The intercellular communication via gap junctions leads, in certain circumstances, to a bioelectric state propagation to neighbor cells, in a chain-like reaction, till an electric discontinuity is reached. However, this is a reversible process, and it was shown experimentally that, by implementing a therapy targeted on cell ion exchange channels, it is possible to reverse the state and repolarize cells. This mechanism can be an important alternative way in cancer prevention, diagnosis and therapy, and new experiments are proposed to test the presented hypothesis.
URI: http://hdl.handle.net/10316/95681
ISSN: 2045-2322
DOI: 34193902
2045-2322
2045-2322
34193902
10.1038/s41598-021-92951-0
34193902
2045-2322
Rights: openAccess
Appears in Collections:I&D CFis - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
s41598-021-92951-0.pdf1.74 MBAdobe PDFView/Open
Show full item record

Page view(s)

51
checked on Sep 24, 2021

Download(s)

8
checked on Sep 24, 2021

Google ScholarTM

Check

Altmetric

Altmetric


This item is licensed under a Creative Commons License Creative Commons